Open Access

Expression of chicken ovalbumin upstream promoter‑transcription factor II and liver X receptor as prognostic indicators for human colorectal cancer

  • Authors:
    • Seong‑Hoon Yun
    • Min‑Gyoung Park
    • Yu‑Mi Kim
    • Mee‑Sook Roh
    • Joo‑In Park
  • View Affiliations

  • Published online on: July 24, 2017     https://doi.org/10.3892/ol.2017.6659
  • Pages: 4011-4020
  • Copyright: © Yun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cholesterol increases the risk of colorectal cancer. Liver X receptor (LXR), retinoid X receptor (RXR)α and sterol regulatory element binding protein (SREBP)‑1c are transcriptional regulators of lipid metabolism. Chicken ovalbumin upstream promoter‑transcription factor II (COUP‑TFII) serves an essential role in angiogenesis and development, but its role in cancer is controversial. The expression of COUP‑TFII, LXR, RXRα and SREBP‑1c in colorectal cancer, as well as their association with clinicopathologic features, was assessed, and their utility as prognostic indicators in colorectal cancer evaluated. Colorectal cancer samples (n=707 patients) were analyzed for COUP‑TII, LXR, RXRα and SREBP‑1c expression by immunohistochemistry. Overall survival curves of patients with tumors expressing different levels of these proteins were produced and risk factors were assessed. Of the 707 patients, 32.7, 50.9, 56.4, and 41.7% were positive for COUP‑TFII, LXR, RXRα, and SREBP‑1c, respectively. The lack of COUP‑TFII or LXR expression was associated with lower overall survival rates (P=0.0154 for COUP‑TFII, and 0.0113 for LXR). Following adjustment for other clinical risk factors (age, sex, tumor size, grade, vascular invasion, and Tumor‑Node‑Metastasis stage), the lack of COUP‑TFII or LXR expression was a negative independent prognostic factor for survival. The expression of COUP‑TFII and LXR alone or in combination may be biomarkers to indicate a positive prognosis in patients with colorectal cancer.
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October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yun SH, Park MG, Kim YM, Roh MS and Park JI: Expression of chicken ovalbumin upstream promoter‑transcription factor II and liver X receptor as prognostic indicators for human colorectal cancer. Oncol Lett 14: 4011-4020, 2017
APA
Yun, S., Park, M., Kim, Y., Roh, M., & Park, J. (2017). Expression of chicken ovalbumin upstream promoter‑transcription factor II and liver X receptor as prognostic indicators for human colorectal cancer. Oncology Letters, 14, 4011-4020. https://doi.org/10.3892/ol.2017.6659
MLA
Yun, S., Park, M., Kim, Y., Roh, M., Park, J."Expression of chicken ovalbumin upstream promoter‑transcription factor II and liver X receptor as prognostic indicators for human colorectal cancer". Oncology Letters 14.4 (2017): 4011-4020.
Chicago
Yun, S., Park, M., Kim, Y., Roh, M., Park, J."Expression of chicken ovalbumin upstream promoter‑transcription factor II and liver X receptor as prognostic indicators for human colorectal cancer". Oncology Letters 14, no. 4 (2017): 4011-4020. https://doi.org/10.3892/ol.2017.6659