Co‑existence of benign gynecological tumors with endometriosis in a group of 1,000 women

Matalliotaki,Charoula; Matalliotakis,Michail; Ieromonachou,Panagiotis; Goulielmos,George  N.; Zervou,Maria   I.; Laliotis,Aggelos; Spandidos,Demetrios  A.; Arici,Aydin; Matalliotakis,Ioannis

doi:10.3892/ol.2017.7449

Co‑existence of benign gynecological tumors with endometriosis in a group of 1,000 women

Authors:
- Charoula Matalliotaki
- Michail Matalliotakis
- Panagiotis Ieromonachou
- George N. Goulielmos
- Maria I. Zervou
- Aggelos Laliotis
- Demetrios A. Spandidos
- Aydin Arici
- Ioannis Matalliotakis
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Affiliations: Department of Obstetrics and Gynecology, Venizeleio General Hospital, 71409 Heraklion, Crete, Greece, Department of Histopathology, Venizeleio General Hospital, 71409 Heraklion, Crete, Greece, Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, 71003 Heraklion, Crete, Greece, Department of General Surgery, Croydon University Hospital, CR7 YE London, UK, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Crete, Greece, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
Published online on: November 20, 2017 https://doi.org/10.3892/ol.2017.7449
Pages: 1529-1532
Copyright: © Matalliotaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The purpose of this study was two-fold, first to investigate the association between endometriosis and the risk of benign gynecologic tumors and, secondly, to evaluate the distribution of endometrioma and ovarian cysts in women with endometriosis. The medical and pathological reports of 1,000 women with endometriosis were retrospectively reviewed. The incidence of ovarian cysts, uterine leiomyomas and adenomyosis, as well as the side of ovarian cysts were further compared. A total of 295 cases of endometriomas, 172 cases of adenomyosis, 173 cases of ovarian cysts and 89 cases of uterine leiomyomas were confirmed histologically in patients with endometriosis. Serous cysts represented the most frequent diagnosis (n=81, 8.1%) in women with ovarian cysts, followed by dermoid cysts (n=15, 1.2%). In women with unilateral endometriomas, the observed proportion of left-sided cysts was found in 65.6% (164 of 250), significantly higher compared with right‑sided cysts (86 out of 250, 34.4%) (P<0.001). Moreover, patients with other ovarian cysts were recognized as left‑sided in 60% (96 out of 160) of cases, significantly higher compared with right‑sided cysts (64 out of 160, 40%) (P<0.01). On the whole, the current study indicates that endometriosis may be associated with an increased risk of benign gynecological tumors, such as ovarian cysts, adenomyosis and leiomyomas. The results of this study confirm a left lateral predisposition of endometriomas and ovarian cysts.

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