Macrophages in skin melanoma-the key element in melanomagenesis (Review)

  • Authors:
    • Malgorzata Pieniazek
    • Rafal Matkowski
    • Piotr Donizy
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  • Published online on: February 9, 2018     https://doi.org/10.3892/ol.2018.8021
  • Pages: 5399-5404
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Abstract

Cutaneous melanoma is an aggressive cancer and its onset and growth are associated, through direct and indirect interactions, with the cancer microenvironment. The microenvironment comprises a dynamic complex of numerous types of cells (due to histogenesis) that constantly interact with each other through multiple cytokines and signaling proteins. Macrophages are one of the most thoroughly studied pleiotropic cells of the immune system. One of their major cytophysiological functions is their involvement in phagocytosis. Previous studies examining the microenvironment of melanomas and tumor‑associated macrophages have revealed that they are involved in all stages of melanomagenesis. In the case of cancer initiation, they form an inflammatory microenvironment and then suppress the anticancer activity of the immune system, stimulate angiogenesis, enhance migration and invasion of the cancer cells, and ultimately contribute to the metastatic process. The present review provides a detailed overview on the function of macrophages in the melanoma microenvironment.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Pieniazek M, Matkowski R and Donizy P: Macrophages in skin melanoma-the key element in melanomagenesis (Review). Oncol Lett 15: 5399-5404, 2018.
APA
Pieniazek, M., Matkowski, R., & Donizy, P. (2018). Macrophages in skin melanoma-the key element in melanomagenesis (Review). Oncology Letters, 15, 5399-5404. https://doi.org/10.3892/ol.2018.8021
MLA
Pieniazek, M., Matkowski, R., Donizy, P."Macrophages in skin melanoma-the key element in melanomagenesis (Review)". Oncology Letters 15.4 (2018): 5399-5404.
Chicago
Pieniazek, M., Matkowski, R., Donizy, P."Macrophages in skin melanoma-the key element in melanomagenesis (Review)". Oncology Letters 15, no. 4 (2018): 5399-5404. https://doi.org/10.3892/ol.2018.8021