Endoplasmic reticulum chaperone glucose-regulated protein 78 in gastric cancer: An emerging biomarker (Review)

  • Authors:
    • Yan Wang
    • Jian‑Hong Wang
    • Xun‑Lei Zhang
    • Xiao‑Li Wang
    • Lei Yang
  • View Affiliations

  • Published online on: February 26, 2018     https://doi.org/10.3892/ol.2018.8114
  • Pages: 6087-6093
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The endoplasmic reticulum (ER) is the principal organelle responsible for the synthesis, initial post-translational modification, folding, export and secretion of proteins. It is also responsible for the maintenance of cellular homeostasis. In response to cellular stress conditions including glucose deprivation, hypoxia and changes in calcium homeostasis, ER stress machinery is activated and triggers the unfolded protein response, resulting in the restoration of homeostasis or activation of cell death. Glucose‑regulated protein 78 (GRP78), a molecular chaperone, may be induced by ER stress at the transcriptional and translational level. A number of studies have demonstrated that GRP78 serves an important role in tumor cell proliferation, metastasis, angiogenesis and drug‑resistance. The present review systematically describes the association between GRP78 expression and gastric cancer pathogenesis, and emphasizes that GRP78 is a novel diagnostic and therapeutic biomarker of gastric cancer.
View Figures
View References

Related Articles

Journal Cover

May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Wang JH, Zhang XL, Wang XL and Yang L: Endoplasmic reticulum chaperone glucose-regulated protein 78 in gastric cancer: An emerging biomarker (Review). Oncol Lett 15: 6087-6093, 2018.
APA
Wang, Y., Wang, J., Zhang, X., Wang, X., & Yang, L. (2018). Endoplasmic reticulum chaperone glucose-regulated protein 78 in gastric cancer: An emerging biomarker (Review). Oncology Letters, 15, 6087-6093. https://doi.org/10.3892/ol.2018.8114
MLA
Wang, Y., Wang, J., Zhang, X., Wang, X., Yang, L."Endoplasmic reticulum chaperone glucose-regulated protein 78 in gastric cancer: An emerging biomarker (Review)". Oncology Letters 15.5 (2018): 6087-6093.
Chicago
Wang, Y., Wang, J., Zhang, X., Wang, X., Yang, L."Endoplasmic reticulum chaperone glucose-regulated protein 78 in gastric cancer: An emerging biomarker (Review)". Oncology Letters 15, no. 5 (2018): 6087-6093. https://doi.org/10.3892/ol.2018.8114