The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications (Review)

  • Authors:
    • Lei Wu
    • Lili Yang
  • View Affiliations

  • Published online on: March 8, 2018     https://doi.org/10.3892/ol.2018.8215
  • Pages: 6799-6805
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Abstract

As a non-histone chromatin-associated protein, high-mobility group box‑1 (HMGB1) performs a pivotal function in various human diseases, including autoimmune diseases, neurodegenerative diseases and cancer. Overexpression of HMGB1 has been demonstrated in numerous types of cancer, including breast cancer, colorectal cancer, lung cancer and hepatocellular carcinoma. However, the underlying mechanism of HMGB1 function in lung cancer remains to be elucidated. The present study aimed to analyze, and summarize the role and mechanism of HMGB1 in lung cancer by retrieving available literature regarding HMGB1 in association with lung cancer. It provides comprehensive information on the association of HMGB1 with the carcinogenesis and progression of lung cancer, and discusses the molecular mechanism of these processes. HMGB1 may induce tumorigenesis, metastasis and chemotherapy resistance in lung cancer. Overall, it is evident that HMGB1 serves an important role in the development and progression of lung cancer, and this review warrants further investigation into HMGB1 as a novel target for cancer therapy.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wu L and Yang L: The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications (Review). Oncol Lett 15: 6799-6805, 2018.
APA
Wu, L., & Yang, L. (2018). The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications (Review). Oncology Letters, 15, 6799-6805. https://doi.org/10.3892/ol.2018.8215
MLA
Wu, L., Yang, L."The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications (Review)". Oncology Letters 15.5 (2018): 6799-6805.
Chicago
Wu, L., Yang, L."The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications (Review)". Oncology Letters 15, no. 5 (2018): 6799-6805. https://doi.org/10.3892/ol.2018.8215