Open Access

Oncogene DEK is highly expressed in lung cancerous tissues and positively regulates cell proliferation as well as invasion

  • Authors:
    • Qian‑Cheng Zhou
    • Xue‑Feng Deng
    • Juan Yang
    • Hong Jiang
    • Ming‑Xu Qiao
    • Huan‑Huan Liu
    • Zhen Qian
    • Ling‑Ling Hou
    • Hong‑Gang Hu
  • View Affiliations

  • Published online on: April 5, 2018     https://doi.org/10.3892/ol.2018.8436
  • Pages: 8573-8581
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

DEK is a protein ubiquitously expressed in multicellular organisms as well as certain unicellular organisms. It is associated with the regulation of cell proliferation, differentiation, migration, apoptosis, senescence, self‑renewal and DNA repairing. In tumor cells it is associated with the carcinogenesis process, however there have been few previous studies into the expression of DEK in lung cancer. In the present study the expression level of DEK mRNA and protein was detected in lung cancer tissues and non‑cancerous counterparts by performing reverse transcription‑quantitative polymerase chain reaction and immunohistochemical staining. It was revealed that the expression of DEK was increased in lung cancer tissues compared with normal tissue. Knock‑down and over‑expression of DEK in A549 cells were performed to determine the role of DEK in tumor formation. An MTT assay, colony formation assay and Matrigel invasion assay demonstrated that DEK positively regulated cell proliferation and invasion. These results suggest that DEK is highly expressed in lung cancer tissues and positively regulates cell proliferation and invasion.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhou QC, Deng XF, Yang J, Jiang H, Qiao MX, Liu HH, Qian Z, Hou LL and Hu HG: Oncogene DEK is highly expressed in lung cancerous tissues and positively regulates cell proliferation as well as invasion. Oncol Lett 15: 8573-8581, 2018
APA
Zhou, Q., Deng, X., Yang, J., Jiang, H., Qiao, M., Liu, H. ... Hu, H. (2018). Oncogene DEK is highly expressed in lung cancerous tissues and positively regulates cell proliferation as well as invasion. Oncology Letters, 15, 8573-8581. https://doi.org/10.3892/ol.2018.8436
MLA
Zhou, Q., Deng, X., Yang, J., Jiang, H., Qiao, M., Liu, H., Qian, Z., Hou, L., Hu, H."Oncogene DEK is highly expressed in lung cancerous tissues and positively regulates cell proliferation as well as invasion". Oncology Letters 15.6 (2018): 8573-8581.
Chicago
Zhou, Q., Deng, X., Yang, J., Jiang, H., Qiao, M., Liu, H., Qian, Z., Hou, L., Hu, H."Oncogene DEK is highly expressed in lung cancerous tissues and positively regulates cell proliferation as well as invasion". Oncology Letters 15, no. 6 (2018): 8573-8581. https://doi.org/10.3892/ol.2018.8436