Research progress on common adverse events caused by targeted therapy for colorectal cancer (Review)
- Authors:
- Bo Zhang
- Chenyan Fang
- Dehou Deng
- Liang Xia
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Affiliations: Department of Integrated Chinese and Western Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Department of Oncology, The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, Department of Neurosurgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China - Published online on: May 7, 2018 https://doi.org/10.3892/ol.2018.8651
- Pages: 27-33
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Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
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 |
 |
|
Kumar B, Bhat ZI, Bansal S, Saini S, Naseem A, Wahabi K, Burman A, Kumar GT, Saluja SS and Rizvi MMA: Association of mitochondrial copy number variation and T16189C polymorphism with colorectal cancer in North Indian population. Tumour Biol. 39:10104283177402962017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang J, Wang TY and Niu XC: Increased plasma levels of pentraxin 3 are associated with poor prognosis of colorectal carcinoma patients. Tohoku J Exp Med. 240:39–46. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Edge SB and Compton CC: The American Joint Committee on cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Kumar SK, Callander NS, Alsina M, Atanackovic D, Biermann JS, Chandler JC, Costello C, Faiman M, Fung HC, Gasparetto C, et al: Multiple myeloma, version 3.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 15:230–269. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Benson AB III, Venook AP, Cederquist L, Chan E, Chen YJ, Cooper HS, Deming D, Engstrom PF, Enzinger PC, Fichera A, et al: Colon cancer, version 1.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 15:370–398. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Gibson RJ, Keefe DM, Lalla RV, Bateman E, Blijlevens N, Fijlstra M, King EE, Stringer AM, van der Velden WJ, Yazbeck R, et al: Systematic review of agents for the management of gastrointestinal mucositis in cancer patients. Support Care Cancer. 21:313–326. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Douillard JY, Oliner KS, Siena S, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, et al: Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med. 369:1023–1034. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Van Cutsem E, Köhne CH, Hitre E, Zaluski J, Chien Chang CR, Makhson A, D'Haens G, Pintér T, Lim R, Bodoky G, et al: Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 360:1408–1417. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Isobe T, Uchino K, Makiyama C, Ariyama H, Arita S, Tamura S, Komoda M, Kusaba H, Shirakawa T, Esaki T, et al: Analysis of adverse events of bevacizumab-containing systemic chemotherapy for metastatic colorectal cancer in Japan. Anticancer Res. 34:2035–2040. 2014.PubMed/NCBI | |
|
Folprecht G, Pericay C, Saunders MP, Thomas A, Lopez Lopez R, Roh JK, Chistyakov V, Höhler T, Kim JS, Hofheinz RD, et al: Oxaliplatin and 5-FU/folinic acid (modified FOLFOX6) with or without aflibercept in first-line treatment of patients with metastatic colorectal cancer: The AFFIRM study. Ann Oncol. 27:1273–1279. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Calcagno F, Lenoble S, Lakkis Z, Nguyen T, Limat S, Borg C, Jary M, Kim S and Nerich V: Efficacy, safety and cost of regorafenib in patients with metastatic colorectal cancer in French clinical practice. Clin Med Insights Oncol. 10:59–66. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang D, Ye J, Xu T and Xiong B: Treatment related severe and fatal adverse events with cetuximab in colorectal cancer patients: A meta-analysis. J Chemother. 25:170–175. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Ferrara N: Vascular endothelial growth factor as a target for anticancer therapy. Oncologist. 9 Suppl 1:S2–S10. 2004. View Article : Google Scholar | |
|
Correale P, Botta C, Ciliberto D, Pastina P, Ingargiola R, Zappavigna S, Tassone P, Pirtoli L, Caraglia M and Tagliaferri P: Immunotherapy of colorectal cancer: New perspectives after a long path. Immunotherapy. 8:1281–1292. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Klein A and Loewenstein A: Therapeutic monoclonal antibodies and fragments: Bevacizumab. Dev Ophthalmol. 55:232–245. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Syed YY and McKeage K: Aflibercept: A review in metastatic colorectal cancer. Drugs. 75:1435–1445. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Sun W: Angiogenesis in metastatic colorectal cancer and the benefits of targeted therapy. J Hematol Oncol. 5:632012. View Article : Google Scholar : PubMed/NCBI | |
|
Shiojima I, Sato K, Izumiya Y, Schiekofer S, Ito M, Liao R, Colucci WS and Walsh K: Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest. 115:2108–2118. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Al-Husseini A, Kraskauskas D, Mezzaroma E, Nordio A, Farkas D, Drake JI, Abbate A, Felty Q and Voelkel NF: Vascular endothelial growth factor receptor 3 signaling contributes to angioobliterative pulmonary hypertension. Pulm Circ. 5:101–116. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Voelkel NF and Gomez-Arroyo J: The role of vascular endothelial growth factor in pulmonary arterial hypertension. The angiogenesis paradox. Am J Respir Cell Mol Biol. 51:474–484. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Robinson ES, Khankin EV, Choueiri TK, Dhawan MS, Rogers MJ, Karumanchi SA and Humphreys BD: Suppression of the nitric oxide pathway in metastatic renal cell carcinoma patients receiving vascular endothelial growth factor-signaling inhibitors. Hypertension. 56:1131–1136. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Gurevich F and Perazella MA: Renal effects of anti-angiogenesis therapy: Update for the internist. Am J Med. 122:322–328. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Kabbinavar FF, Schulz J, McCleod M, Patel T, Hamm JT, Hecht JR, Mass R, Perrou B, Nelson B and Novotny WF: Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial. J Clin Oncol. 23:3697–3705. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Yoshida M, Muro K, Tsuji A, Hamamoto Y, Yoshino T, Yoshida K, Shirao K, Miyata Y, Takahari D, Takahashi T and Ohtsu A: Combination chemotherapy with bevacizumab and S-1 for elderly patients with metastatic colorectal cancer (BASIC trial). Eur J Cancer. 51:935–941. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Qi WX, Shen Z, Tang LN and Yao Y: Risk of hypertension in cancer patients treated with aflibercept: A systematic review and meta-analysis. Clin Drug Investig. 34:231–240. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Chen J, Lu Y and Zheng Y: Incidence and risk of hypertension with bevacizumab in non-small-cell lung cancer patients: A meta-analysis of randomized controlled trials. Drug Des Devel Ther. 9:4751–4760. 2015.PubMed/NCBI | |
|
Sclafani F and Cunningham D: Bevacizumab in elderly patients with metastatic colorectal cancer. J Geriatr Oncol. 5:78–88. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Hamnvik OP, Choueiri TK, Turchin A, McKay RR, Goyal L, Davis M, Kaymakcalan MD and Williams JS: Clinical risk factors for the development of hypertension in patients treated with inhibitors of the VEGF signaling pathway. Cancer. 121:311–319. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Hurwitz H and Saini S: Bevacizumab in the treatment of metastatic colorectal cancer: Safety profile and management of adverse events. Semin Oncol. 33 5 Suppl 10:S26–S34. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Pande A, Lombardo J, Spangenthal E and Javle M: Hypertension secondary to anti-angiogenic therapy: Experience with bevacizumab. Anticancer Res. 27:3465–3470. 2007.PubMed/NCBI | |
|
Izzedine H, Massard C, Spano JP, Goldwasser F, Khayat D and Soria JC: VEGF signalling inhibition-induced proteinuria: Mechanisms, significance and management. Eur J Cancer. 46:439–448. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Yang JC, Haworth L, Sherry RM, Hwu P, Schwartzentruber DJ, Topalian SL, Steinberg SM, Chen HX and Rosenberg SA: A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med. 349:427–434. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Eremina V, Sood M, Haigh J, Nagy A, Lajoie G, Ferrara N, Gerber HP, Kikkawa Y, Miner JH and Quaggin SE: Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest. 111:707–716. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Dimke H, Sparks MA, Thomson BR, Frische S, Coffman TM and Quaggin SE: Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney. J Am Soc Nephrol. 26:1027–1038. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu X, Wu S, Dahut WL and Parikh CR: Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: Systematic review and meta-analysis. Am J Kidney Dis. 49:186–193. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang ZF, Wang T, Liu LH and Guo HQ: Risks of proteinuria associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors in cancer patients: A systematic review and meta-analysis. PLoS One. 9:e901352014. View Article : Google Scholar : PubMed/NCBI | |
|
Izzedine H, Rixe O, Billemont B, Baumelou A and Deray G: Angiogenesis inhibitor therapies: Focus on kidney toxicity and hypertension. Am J Kidney Dis. 50:203–218. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Faruque LI, Lin M, Battistella M, Wiebe N, Reiman T, Hemmelgarn B, Thomas C and Tonelli M: Systematic review of the risk of adverse outcomes associated with vascular endothelial growth factor inhibitors for the treatment of cancer. PLoS One. 9:e1011452014. View Article : Google Scholar : PubMed/NCBI | |
|
Qi WX, Sun YJ, Tang LN, Shen Z and Yao Y: Risk of gastrointestinal perforation in cancer patients treated with vascular endothelial growth factor receptor tyrosine kinase inhibitors: A systematic review and meta-analysis. Crit Rev Oncol Hematol. 89:394–403. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Cartwright TH: Adverse events associated with antiangiogenic agents in combination with cytotoxic chemotherapy in metastatic colorectal cancer and their management. Clin Colorectal Cancer. 12:86–94. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Grenon NN: Managing toxicities associated with antiangiogenic biologic agents in combination with chemotherapy for metastatic colorectal cancer. Clin J Oncol Nurs. 17:425–433. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Tabernero J, Takayuki Y and Cohn AL: Correction to Lancet Oncol 2015; 16: 499–508. Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): A randomised, double-blind, multicentre, phase 3 study. Lancet Oncol. 16:e2622015.PubMed/NCBI | |
|
Liu S and Kurzrock R: Toxicity of targeted therapy: Implications for response and impact of genetic polymorphisms. Cancer Treat Rev. 40:883–891. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Economopoulou P, Kotsakis A, Kapiris I and Kentepozidis N: Cancer therapy and cardiovascular risk: Focus on bevacizumab. Cancer Manag Res. 7:133–143. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Van Cutsem E, Rivera F, Berry S, Kretzschmar A, Michael M, DiBartolomeo M, Mazier MA, Canon JL, Georgoulias V, Peeters M, et al: Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: The BEAT study. Ann Oncol. 20:1842–1847. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
McLellan B, Ciardiello F, Lacouture ME, Segaert S and Van Cutsem E: Regorafenib-associated hand-foot skin reaction: Practical advice on diagnosis, prevention, and management. Ann Oncol. 26:2017–2026. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Elmalik HH, ElAzzazy S, Salem KS and Bujassoum S: A grave outcome of posterior reversible encephalopathy syndrome in a patient receiving avastin (Bevacizumab) for metastatic High-grade serous ovarian cancer. Case Rep Oncol. 8:290–294. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Ayuso-Sacido A, Moliterno JA, Kratovac S, Kapoor GS, O'Rourke DM, Holland EC, García-Verdugo JM, Roy NS and Boockvar JA: Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells. J Neurooncol. 97:323–337. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Takahashi N, Yamada Y, Furuta K, Honma Y, Iwasa S, Takashima A, Kato K, Hamaguchi T and Shimada Y: Serum levels of hepatocyte growth factor and epiregulin are associated with the prognosis on anti-EGFR antibody treatment in KRAS wild-type metastatic colorectal cancer. Br J Cancer. 110:2716–2727. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Hasegawa Y, Ando M, Maemondo M, Yamamoto S, Isa S, Saka H, Kubo A, Kawaguchi T, Takada M, Rosell R, et al: The role of smoking status on the progression-free survival of non-small cell lung cancer patients harboring activating epidermal growth factor receptor (EGFR) mutations receiving first-line EGFR tyrosine kinase inhibitor versus platinum doublet chemotherapy: A meta-analysis of prospective randomized trials. Oncologist. 20:307–315. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Philip PA and Lutz MP: Targeting epidermal growth factor receptor-related signaling pathways in pancreatic cancer. Pancreas. 44:1046–1052. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Groenestege WM, Thébault S, van der Wijst J, van den Berg D, Janssen R, Tejpar S, van den Heuvel LP, van Cutsem E, Hoenderop JG, Knoers NV and Bindels RJ: Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia. J Clin Invest. 117:2260–2267. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Petrelli F, Borgonovo K, Cabiddu M, Ghilardi M and Barni S: Risk of anti-EGFR monoclonal antibody-related hypomagnesemia: Systematic review and pooled analysis of randomized studies. Expert Opin Drug Saf. 11 Suppl 1:S9–S19. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Maliakal P and Ledford A: Electrolyte and protein imbalance following anti-EGFR therapy in cancer patients: A comparative study. Exp Ther Med. 1:307–311. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Fakih MG, Wilding G and Lombardo J: Cetuximab-induced hypomagnesemia in patients with colorectal cancer. Clin Colorectal Cancer. 6:152–156. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Chen P, Wang L, Li H, Liu B and Zou Z: Incidence and risk of hypomagnesemia in advanced cancer patients treated with cetuximab: A meta-analysis. Oncol Lett. 5:1915–1920. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Cao Y, Liao C, Tan A, Liu L and Gao F: Meta-analysis of incidence and risk of hypomagnesemia with cetuximab for advanced cancer. Chemotherapy. 56:459–465. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Tejpar S, Piessevaux H, Claes K, Piront P, Hoenderop JG, Verslype C and Van Cutsem E: Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: A prospective study. Lancet Oncol. 8:387–394. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Streb J, Püsküllüoğlu M, Glanowska I, Ochenduszko S, Konopka K, Łupkowski R, Michalowska-Kaczmarczyk A, Bochenek-Cibor J, Majka M and Krzemieniecki K: Assessment of frequency and severity of hypomagnesemia in patients with metastatic colorectal cancer treated with cetuximab, with a review of the literature. Oncol Lett. 10:3749–3755. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
de Baaij JH, Hoenderop JG and Bindels RJ: Magnesium in man: Implications for health and disease. Physiol Rev. 95:1–46. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Cosmai L, Gallieni M and Porta C: Renal toxicity of anticancer agents targeting HER2 and EGFR. J Nephrol. 28:647–657. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Arora N, Gupta A and Singh PP: Biological agents in gastrointestinal cancers: Adverse effects and their management. J Gastrointest Oncol. 8:485–498. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Cao Y, Liu L, Liao C, Tan A and Gao F: Meta-analysis of incidence and risk of hypokalemia with cetuximab-based therapy for advanced cancer. Cancer Chemother Pharmacol. 66:37–42. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Dimke H, Monnens L, Hoenderop JG and Bindels RJ: Evaluation of hypomagnesemia: Lessons from disorders of tubular transport. Am J Kidney Dis. 62:377–383. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Q, Qi Y, Zhang D, Gong C, Yao A, Xiao Y, Yang J, Zhou F and Zhou Y: Electrolyte disorders assessment in solid tumor patients treated with anti-EGFR monoclonal antibodies: A pooled analysis of 25 randomized clinical trials. Tumour Biol. 36:3471–3482. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Geyikoglu F, Emir M, Colak S, Koc K, Turkez H, Bakir M, Hosseinigouzdagani M, Cerig S, Keles ON and Ozek NS: Effect of oleuropein against chemotherapy drug-induced histological changes, oxidative stress, and DNA damages in rat kidney injury. J Food Drug Anal. 25:447–459. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Oh CJ, Ha CM, Choi YK, Park S, Choe MS, Jeoung NH, Huh YH, Kim HJ, Kweon HS, Lee JM, et al: Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury. Kidney Int. 91:880–895. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Abbas A, Mirza MM, Ganti AK and Tendulkar K: Renal toxicities of targeted therapies. Target Oncol. 10:487–499. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Qi WX, Sun YJ, Shen Z and Yao Y: Risk of anti-EGFR monoclonal antibody-related skin rash: An up-to-date meta-analysis of 25 randomized controlled trials. J Chemother. 26:359–368. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Vaubel J, Livingstone E, Schadendorf D and Zimmer L: Retarded low-dose doxycycline for EGFR or MEK inhibitor-induced papulopustular rash. J Eur Acad Dermatol Venereol. 28:1685–1689. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Singh N, Vishwanath G, Aggarwal AN and Behera D: Clinical experience on use of oral EGFR-TKIs as first-line treatment of advanced NSCLC from a tertiary care centre in North India and implications of skin rash. Indian J Chest Dis Allied Sci. 56:149–152. 2014.PubMed/NCBI | |
|
Liu HB, Wu Y, Lv TF, Yao YW, Xiao YY, Yuan DM and Song Y: Skin rash could predict the response to EGFR tyrosine kinase inhibitor and the prognosis for patients with non-small cell lung cancer: A systematic review and meta-analysis. PLoS One. 8:e551282013. View Article : Google Scholar : PubMed/NCBI | |
|
Jaka A, Gutiérrez-Rivera A, Ormaechea N, Blanco J, La Casta A, Sarasqueta C, Izeta A and Tuneu A: Association between EGFR gene polymorphisms, skin rash and response to anti-EGFR therapy in metastatic colorectal cancer patients. Exp Dermatol. 23:751–753. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ocvirk J, Heeger S, McCloud P and Hofheinz RD: A review of the treatment options for skin rash induced by EGFR-targeted therapies: Evidence from randomized clinical trials and a meta-analysis. Radiol Oncol. 47:166–175. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Gerber PA, Meller S, Eames T, Buhren BA, Schrumpf H, Hetzer S, Ehmann LM, Budach W, Bölke E, Matuschek C, et al: Management of EGFR-inhibitor associated rash: A retrospective study in 49 patients. Eur J Med Res. 17:42012. View Article : Google Scholar : PubMed/NCBI | |
|
Eaby-Sandy B and Lynch K: Side effects of targeted therapies: Rash. Semin Oncol Nurs. 30:147–154. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Stremitzer S, Sebio A, Stintzing S and Lenz HJ: Panitumumab safety for treating colorectal cancer. Expert Opin Drug Saf. 13:843–851. 2014.PubMed/NCBI | |
|
Lv ZC, Ning JY and Chen HB: Efficacy and toxicity of adding cetuximab to chemotherapy in the treatment of metastatic colorectal cancer: A meta-analysis from 12 randomized controlled trials. Tumour Biol. 35:11741–11750. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
André T and Dumont SN: Regorafenib approved in metastatic colorectal cancer. Bull Cancer. 100:1027–1029. 2013.(In French). PubMed/NCBI | |
|
Saif MW, Syrigos KI, Hotchkiss S, Shanley J, Grasso J, Ferencz TM, Syrigos K and Shah MM: Successful desensitization with cetuximab after an infusion reaction to panitumumab in patients with metastatic colorectal cancer. Cancer Chemother Pharmacol. 65:107–112. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Garcia-Foncillas J and Diaz-Rubio E: Progress in metastatic colorectal cancer: Growing role of cetuximab to optimize clinical outcome. Clin Transl Oncol. 12:533–542. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Emmanouilides C, Sfakiotaki G, Androulakis N, Kalbakis K, Christophylakis C, Kalykaki A, Vamvakas L, Kotsakis A, Agelaki S, Diamandidou E, et al: Front-line bevacizumab in combination with oxaliplatin, leucovorin and 5-fluorouracil (FOLFOX) in patients with metastatic colorectal cancer: A multicenter phase II study. BMC Cancer. 7:912007. View Article : Google Scholar : PubMed/NCBI | |
|
Douillard JY, Siena S, Cassidy J, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, et al: Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study. J Clin Oncol. 28:4697–4705. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Saltz LB, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R, Koski S, Lichinitser M, Yang TS, Rivera F, et al: Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study. J Clin Oncol. 26:2013–2019. 2008. View Article : Google Scholar : PubMed/NCBI |
