Open Access

Combination therapy: A feasibility strategy for CAR‑T cell therapy in the treatment of solid tumors (Review)

  • Authors:
    • Jinjing Xu
    • Yali Wang
    • Jing Shi
    • Juan Liu
    • Qingguo Li
    • Longzhou Chen
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  • Published online on: June 11, 2018     https://doi.org/10.3892/ol.2018.8946
  • Pages: 2063-2070
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chimeric antigen receptor (CAR) T‑cell therapies have been demonstrated to have durable and potentially curative therapeutic efficacies in patients with hematological malignancies. Currently, multiple clinical trials in CAR‑T cell therapy have been evaluated for the treatment of patients with solid malignancies, but have had less marked therapeutic effects when the agents are used as monotherapies. When summarizing relevant studies, the present study found that combination therapy strategies for solid tumors based on CAR‑T cell therapies might be more effective. This review will focus on various aspects of treating solid tumors with CAR‑T cell therapy: i) The therapeutic efficacy of CAR‑T cell monotherapy, ii) the feasibility of the CAR‑T cell therapy in conjunction with chemotherapy, iii) the feasibility of CAR‑T cell therapy with radiotherapy, iv) the feasibility of CAR‑T cell therapy with chemoradiotherapy, and v) the feasibility of the combination of CAR‑T cell therapy with other strategies.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xu J, Wang Y, Shi J, Liu J, Li Q and Chen L: Combination therapy: A feasibility strategy for CAR‑T cell therapy in the treatment of solid tumors (Review). Oncol Lett 16: 2063-2070, 2018.
APA
Xu, J., Wang, Y., Shi, J., Liu, J., Li, Q., & Chen, L. (2018). Combination therapy: A feasibility strategy for CAR‑T cell therapy in the treatment of solid tumors (Review). Oncology Letters, 16, 2063-2070. https://doi.org/10.3892/ol.2018.8946
MLA
Xu, J., Wang, Y., Shi, J., Liu, J., Li, Q., Chen, L."Combination therapy: A feasibility strategy for CAR‑T cell therapy in the treatment of solid tumors (Review)". Oncology Letters 16.2 (2018): 2063-2070.
Chicago
Xu, J., Wang, Y., Shi, J., Liu, J., Li, Q., Chen, L."Combination therapy: A feasibility strategy for CAR‑T cell therapy in the treatment of solid tumors (Review)". Oncology Letters 16, no. 2 (2018): 2063-2070. https://doi.org/10.3892/ol.2018.8946