Adenoid cystic carcinoma of the larynx in a 70-year-old patient: A case report

Ricciardiello,Filippo; Addeo,Raffaele; Di Lullo,Antonella Miriam; Abate,Teresa; Mazzone,Salvatore; Oliva,Flavia; Motta,Giovanni; Caraglia,Michelle; Mesolella,Massimo

doi:10.3892/ol.2018.8976

Adenoid cystic carcinoma of the larynx in a 70-year-old patient: A case report

Authors:
- Filippo Ricciardiello
- Raffaele Addeo
- Antonella Miriam Di Lullo
- Teresa Abate
- Salvatore Mazzone
- Flavia Oliva
- Giovanni Motta
- Michelle Caraglia
- Massimo Mesolella
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Affiliations: Ear Nose and Throat Unit, ‘Antonio Cardarelli’ Hospital, I-80131 Naples, Naples, Italy, Oncology Unit, ‘San Giovanni di Dio’ Hospital, I-80027 Naples, Italy, Department of Neuroscience, Reproductive and Odontostomatological Science, Ear Nose and Throat Unit, University of Naples ‘Federico II’, I-80131 Naples, Italy, Department of Mental and Physical Health and Preventive Medicine, University of Campania ‘L. Vanvitelli’, I-80138 Naples, Italy, Department of Precision Medicine, University of Campania ‘L. Vanvitelli’, I-80138 Naples, Italy
Published online on: June 18, 2018 https://doi.org/10.3892/ol.2018.8976
Pages: 2783-2788
Copyright: © Ricciardiello et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Adenoid cystic carcinoma (ACC) is a relatively rare tumor that accounts for <1% of all head and neck malignancies. Laryngeal localization of ACC, which is most commonly hypoglottic, is relatively rare, occurring in 0.07‑0.25% of all laryngeal tumors. ACC is characterized as a slow-growing tumor with a high recurrence rate, which often causes dyspnea and hoarseness. ACC exhibits a propensity for perineural invasion and thus, patients may experience pain as a late symptom of the disease. Distant metastasis occurs in 35-50% of cases and the lungs are the most common site of metastasis. Tumors are usually diagnosed by physical examination with fiberoscopy and computed tomography of the neck and chest, due to the high rate of lung metastases. The standard therapy for ACC is surgery followed by radiotherapy. In this study, a 70-year-old patient presented with laryngeal ACC, who underwent total laryngectomy with bilateral neck dissection and adjuvant radiotherapy, is presented. Follow‑up examination performed 2 years after surgery revealed no evidence of locoregional recurrence or distant metastases. Previously published literature regarding ACC of the larynx was also reviewed.

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