Spindle cell melanoma: Incidence and survival, 1973‑2017

Xu,Zhe; Shi,Ping; Yibulayin,Feiluore; Feng,Lei; Zhang,Hao; Wushou,Alimujiang

doi:10.3892/ol.2018.9247

Spindle cell melanoma: Incidence and survival, 1973‑2017

Authors:
- Zhe Xu
- Ping Shi
- Feiluore Yibulayin
- Lei Feng
- Hao Zhang
- Alimujiang Wushou
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Affiliations: Department of Stomatology, Shenzhen Longhua District Central Hospital, Guangdong Medical University, Shenzhen, Guangdong 518110, P.R. China, Department of Oral and Maxillofacial Surgery, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, P.R. China, Department of Oral Biomedical Engineering Laboratory, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, P.R. China
Published online on: August 1, 2018 https://doi.org/10.3892/ol.2018.9247
Pages: 5091-5099
Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Spindle cell melanoma (SCM) is a rare morphological subtype of melanoma, which is relatively uncharacterized. The aim of the present study was to investigate the incidence of SCM, its general demographics, basic clinico‑pathologic features, treatment outcomes and disease‑specific prognostic factors. SCM cases were sampled from the Surveillance, Epidemiology and End Results (SEER) Program (1973‑2017). A total of 4761 SCM cases were identified, with a median age of 66 years. The female:male ratio was 0.62:1. Statistically significant overall survival (OS) and disease‑specific survival (DSS) rate differences were identified depending on age, sex, ethnicity, tumor location, T stage, N stage, M stage, pathological grade, AJCC stage, SEER stages and surgical treatment (P<0.05). Multivariate Cox regression analysis revealed that age >66 years, T3+T4 stage disease, positive N stage and SEER historic stage of regional and distant metastasis tumor were associated with poor DSS and OS rates. In summary, SCM was most common in Caucasian people of 60~80 years of age with a predominance in males. Patient's age, ethnicity, T stage, N stage, and SEER historic stage were identified as independent prognostic factors of SCM in terms of DSS and OS.

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