Open Access

Precision medicine based on tumorigenic signaling pathways for triple‑negative breast cancer (Review)

  • Authors:
    • Nan Wu
    • Jinghua Zhang
    • Jing Zhao
    • Kun Mu
    • Jun Zhang
    • Zhao Jin
    • Jinpu Yu
    • Juntian Liu
  • View Affiliations

  • Published online on: August 10, 2018     https://doi.org/10.3892/ol.2018.9290
  • Pages: 4984-4996
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As a clinically heterogeneous subtype of breast cancer, triple‑negative breast cancer (TNBC) is associated with a poor clinical outcome and a high relapse rate. Conventional chemotherapy and radiotherapy are effective treatments for patients with TNBC. However, the prognosis of TNBC remains unsatisfactory. Therefore, a large volume of research has explored the molecular markers and oncogenic signaling pathways associated with TNBC, including the cell cycle, DNA damage response and androgen receptor (AR) signaling pathways, to identify more efficient targeted therapies. However, whether these predicted pathways are effective targets has yet to be confirmed. In the present review, potentially carcinogenic signaling pathways in TNBCs from previous reports were considered, and ultimately five tumorigenic signaling pathways were selected, specifically receptor tyrosine kinases and downstream signaling pathways, the epithelial‑to‑mesenchymal transition and associated pathways, the immunoregulatory tumor microenvironment, DNA damage repair pathways, and AR and coordinating pathways. The conclusions of the preclinical and clinical trials of each pathway were then consolidated. Although a number of signaling pathways in TNBC have been considered in preclinical and clinical trials, the aforementioned pathways account for the majority of the malignant behaviors of TNBC. Identifying the alterations to different carcinogenic signaling pathways and their association with the heterogeneity of TNBC may facilitate the development of optimal precision medical approaches for patients with TNBC, potentially improving the efficiency of anticancer therapy.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wu N, Zhang J, Zhao J, Mu K, Zhang J, Jin Z, Yu J and Liu J: Precision medicine based on tumorigenic signaling pathways for triple‑negative breast cancer (Review). Oncol Lett 16: 4984-4996, 2018.
APA
Wu, N., Zhang, J., Zhao, J., Mu, K., Zhang, J., Jin, Z. ... Liu, J. (2018). Precision medicine based on tumorigenic signaling pathways for triple‑negative breast cancer (Review). Oncology Letters, 16, 4984-4996. https://doi.org/10.3892/ol.2018.9290
MLA
Wu, N., Zhang, J., Zhao, J., Mu, K., Zhang, J., Jin, Z., Yu, J., Liu, J."Precision medicine based on tumorigenic signaling pathways for triple‑negative breast cancer (Review)". Oncology Letters 16.4 (2018): 4984-4996.
Chicago
Wu, N., Zhang, J., Zhao, J., Mu, K., Zhang, J., Jin, Z., Yu, J., Liu, J."Precision medicine based on tumorigenic signaling pathways for triple‑negative breast cancer (Review)". Oncology Letters 16, no. 4 (2018): 4984-4996. https://doi.org/10.3892/ol.2018.9290