Open Access

MicroRNA‑34a inhibits metastasis in liver cancer cells

  • Authors:
    • Wei Wei
    • Huihuan Tang
    • Ling Tang
  • View Affiliations

  • Published online on: October 9, 2018     https://doi.org/10.3892/ol.2018.9555
  • Pages: 6960-6965
  • Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRNA/miRs) have the ability to target specific mRNAs, resulting in degradation of mRNA or inhibition of translation. Notably, miR‑34a is able to regulate cell cycle and tumorigenicity. The level of miR‑34a expression is usually low in tumors, and previous studies have indicated miR‑34a to be an important tumor suppressor. In order to elucidate the association between miR‑34a and metastasis, stable cell lines were established and transfected with miR‑34a. Cell invasion assay was subsequently performed. The present study demonstrated that cell invasion was inhibited in cells that were transfected with miR‑34a compared with the control group (P<0.05). Therefore, miR‑34a was able to inhibit metastasis in liver cancer cells.
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December-2018
Volume 16 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wei W, Tang H and Tang L: MicroRNA‑34a inhibits metastasis in liver cancer cells. Oncol Lett 16: 6960-6965, 2018
APA
Wei, W., Tang, H., & Tang, L. (2018). MicroRNA‑34a inhibits metastasis in liver cancer cells. Oncology Letters, 16, 6960-6965. https://doi.org/10.3892/ol.2018.9555
MLA
Wei, W., Tang, H., Tang, L."MicroRNA‑34a inhibits metastasis in liver cancer cells". Oncology Letters 16.6 (2018): 6960-6965.
Chicago
Wei, W., Tang, H., Tang, L."MicroRNA‑34a inhibits metastasis in liver cancer cells". Oncology Letters 16, no. 6 (2018): 6960-6965. https://doi.org/10.3892/ol.2018.9555