Opportunities and challenges of co‑targeting epidermal growth factor receptor and autophagy signaling in non‑small cell lung cancer (Review)

  • Authors:
    • Xiaoju Wang
    • Wenxin Li
    • Ni Zhang
    • Xiaoli Zheng
    • Zhao Jing
  • View Affiliations

  • Published online on: May 20, 2019     https://doi.org/10.3892/ol.2019.10372
  • Pages: 499-506
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Abstract

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‑TKIs) are a standard therapy for patients with non‑small cell lung cancer (NSCLC) with sensitive mutations. However, acquired resistance emerges following a median of 6‑12 months. Several studies demonstrated that EGFR‑TKI‑induced tumor microenvironment stresses and autophagy are important causes of resistance. The current review summarizes the molecular mechanisms involved in EGFR‑mediated regulation of autophagy. The role of autophagy in EGFR‑TKI treatment, which may serve a role in protection or cell death, was discussed. Furthermore, co‑inhibiting EGFR and autophagy signaling as a rational therapeutic strategy in the treatment of patients with NSCLC was explored.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang X, Li W, Zhang N, Zheng X and Jing Z: Opportunities and challenges of co‑targeting epidermal growth factor receptor and autophagy signaling in non‑small cell lung cancer (Review). Oncol Lett 18: 499-506, 2019.
APA
Wang, X., Li, W., Zhang, N., Zheng, X., & Jing, Z. (2019). Opportunities and challenges of co‑targeting epidermal growth factor receptor and autophagy signaling in non‑small cell lung cancer (Review). Oncology Letters, 18, 499-506. https://doi.org/10.3892/ol.2019.10372
MLA
Wang, X., Li, W., Zhang, N., Zheng, X., Jing, Z."Opportunities and challenges of co‑targeting epidermal growth factor receptor and autophagy signaling in non‑small cell lung cancer (Review)". Oncology Letters 18.1 (2019): 499-506.
Chicago
Wang, X., Li, W., Zhang, N., Zheng, X., Jing, Z."Opportunities and challenges of co‑targeting epidermal growth factor receptor and autophagy signaling in non‑small cell lung cancer (Review)". Oncology Letters 18, no. 1 (2019): 499-506. https://doi.org/10.3892/ol.2019.10372