Curcumin enhances cisplatin sensitivity by suppressing NADPH oxidase 5 expression in human epithelial cancer

  • Authors:
    • Siqi Chen
    • Wei Gao
    • Min‑Juan Zhang
    • Jimmy Yu‑Wai Chan
    • Thian‑Sze Wong
  • View Affiliations

  • Published online on: June 14, 2019     https://doi.org/10.3892/ol.2019.10479
  • Pages: 2132-2139
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Abstract

Cisplatin‑based chemotherapy regimens serve a pivotal role in human cancer treatment. Nevertheless, treatment failure may occur if the cancer is inherently resistant to cisplatin or acquires a resistant phenotype during the course of treatment. Although cisplatin resistance can hinder the efficacy of cisplatin treatment for human cancer, the underlying mechanism remains poorly understood. The current study established a cisplatin‑resistant human epithelial cancer cell line. Notably, differential upregulation of NADPH oxidase 5 (NOX5) was identified in this resistant cell line. Furthermore, cisplatin treatment induced cancer cells to express NOX5 and cells that overexpressed NOX5 exhibited greater resistance to cisplatin via the activation of Akt. Treatment with curcumin may suppress NOX5 expression in cancer cells and enhance sensitivity to cisplatin treatment. In a xenograft model, a combined regimen of cisplatin with low‑dose curcumin significantly reduced malignant tumor growth. These data demonstrate that curcumin has a chemosensitizing effect on cisplatin‑resistant epithelial cancer types. Therefore, the use of curcumin in addition to a cisplatin‑based treatment regimen may improve treatment outcomes in human patients with epithelial cancer.
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August-2019
Volume 18 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chen S, Gao W, Zhang MJ, Chan JY and Wong TS: Curcumin enhances cisplatin sensitivity by suppressing NADPH oxidase 5 expression in human epithelial cancer. Oncol Lett 18: 2132-2139, 2019.
APA
Chen, S., Gao, W., Zhang, M., Chan, J.Y., & Wong, T. (2019). Curcumin enhances cisplatin sensitivity by suppressing NADPH oxidase 5 expression in human epithelial cancer. Oncology Letters, 18, 2132-2139. https://doi.org/10.3892/ol.2019.10479
MLA
Chen, S., Gao, W., Zhang, M., Chan, J. Y., Wong, T."Curcumin enhances cisplatin sensitivity by suppressing NADPH oxidase 5 expression in human epithelial cancer". Oncology Letters 18.2 (2019): 2132-2139.
Chicago
Chen, S., Gao, W., Zhang, M., Chan, J. Y., Wong, T."Curcumin enhances cisplatin sensitivity by suppressing NADPH oxidase 5 expression in human epithelial cancer". Oncology Letters 18, no. 2 (2019): 2132-2139. https://doi.org/10.3892/ol.2019.10479