Open Access

Survival‑related risk score of lung adenocarcinoma identified by weight gene co‑expression network analysis

  • Authors:
    • He Wang
    • Di Lu
    • Xiguang Liu
    • Jianjun Jiang
    • Siyang Feng
    • Xiaoying Dong
    • Xiaoshun Shi
    • Hua Wu
    • Gang Xiong
    • Haofei Wang
    • Kaican Cai
  • View Affiliations

  • Published online on: September 4, 2019     https://doi.org/10.3892/ol.2019.10795
  • Pages: 4441-4448
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to identify the novel biomarkers and underlying molecular mechanisms of lung adenocarcinoma (LAC) to aid in its diagnosis, prognosis, prediction, disease monitoring and emerging therapies. Data from a total of 498 LAC samples were collected from The Cancer Genome Atlas and divided into two sets by stratified randomization based on pathological Tumor‑Node‑Metastasis stage. The training set was comprised of 348 samples and the validation set was comprised of 150 samples. A total of 123 samples from the training set for patients who completed follow‑up were analyzed by weighted gene co‑expression network analysis. A module was identified that contained 113 protein‑coding genes that were positively associated with overall survival (OS). A least absolute shrinkage and selection operator (LASSO) Cox regression model was constructed and four survival‑associated genes (OPN3, GALNT2, FAM83A and KYNU) were retained. Risk score, calculated by the linear combination of each gene expression multiplied by the LASSO coefficient, could successfully discriminate between patients with LAC exhibiting low and high OS time in both sets. The results from the present study indicate that this risk score may contribute to potential diagnostic and therapeutic strategies for LAC management.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang H, Lu D, Liu X, Jiang J, Feng S, Dong X, Shi X, Wu H, Xiong G, Wang H, Wang H, et al: Survival‑related risk score of lung adenocarcinoma identified by weight gene co‑expression network analysis. Oncol Lett 18: 4441-4448, 2019.
APA
Wang, H., Lu, D., Liu, X., Jiang, J., Feng, S., Dong, X. ... Cai, K. (2019). Survival‑related risk score of lung adenocarcinoma identified by weight gene co‑expression network analysis. Oncology Letters, 18, 4441-4448. https://doi.org/10.3892/ol.2019.10795
MLA
Wang, H., Lu, D., Liu, X., Jiang, J., Feng, S., Dong, X., Shi, X., Wu, H., Xiong, G., Wang, H., Cai, K."Survival‑related risk score of lung adenocarcinoma identified by weight gene co‑expression network analysis". Oncology Letters 18.5 (2019): 4441-4448.
Chicago
Wang, H., Lu, D., Liu, X., Jiang, J., Feng, S., Dong, X., Shi, X., Wu, H., Xiong, G., Wang, H., Cai, K."Survival‑related risk score of lung adenocarcinoma identified by weight gene co‑expression network analysis". Oncology Letters 18, no. 5 (2019): 4441-4448. https://doi.org/10.3892/ol.2019.10795