MicroRNA‑34a inhibits bladder cancer cell migration and invasion, and upregulates PTEN expression

  • Authors:
    • Zhen-Shan Ding
    • Yu-Hui He
    • Yi-Sen Deng
    • Pan-Xin Peng
    • Jian-Feng Wang
    • Xing Chen
    • Pei-Yu Zhao
    • Xiao-Feng Zhou
  • View Affiliations

  • Published online on: September 18, 2019     https://doi.org/10.3892/ol.2019.10877
  • Pages: 5549-5554
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Abstract

MicroRNA‑34a (miR‑34a) serves as a tumor suppressor in a number of different types of cancer. The present study was performed to investigate the involvement of miR‑34a in bladder cancer. In the present study, miR‑34a was downregulated in patients with bladder cancer compared with the healthy controls in bladder biopsies and plasma. Downregulation of miR‑34a distinguished between patients with bladder cancer and the healthy controls. miR‑34a expression was associated with tumor metastasis; however, not with tumor size. Transfection of miR‑34a mimics upregulated the expression of phosphatase and tensin homolog (PTEN) in bladder cancer cells, and decreased cell migration and invasion. miR‑34a may inhibit bladder cancer cell migration and invasion by upregulating PTEN. miR‑34a may additionally serve as a potential therapeutic target for bladder cancer.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ding Z, He Y, Deng Y, Peng P, Wang J, Chen X, Zhao P and Zhou X: MicroRNA‑34a inhibits bladder cancer cell migration and invasion, and upregulates PTEN expression. Oncol Lett 18: 5549-5554, 2019
APA
Ding, Z., He, Y., Deng, Y., Peng, P., Wang, J., Chen, X. ... Zhou, X. (2019). MicroRNA‑34a inhibits bladder cancer cell migration and invasion, and upregulates PTEN expression. Oncology Letters, 18, 5549-5554. https://doi.org/10.3892/ol.2019.10877
MLA
Ding, Z., He, Y., Deng, Y., Peng, P., Wang, J., Chen, X., Zhao, P., Zhou, X."MicroRNA‑34a inhibits bladder cancer cell migration and invasion, and upregulates PTEN expression". Oncology Letters 18.5 (2019): 5549-5554.
Chicago
Ding, Z., He, Y., Deng, Y., Peng, P., Wang, J., Chen, X., Zhao, P., Zhou, X."MicroRNA‑34a inhibits bladder cancer cell migration and invasion, and upregulates PTEN expression". Oncology Letters 18, no. 5 (2019): 5549-5554. https://doi.org/10.3892/ol.2019.10877