Open Access

Radioimmunoimaging of 125I‑labeled anti‑CD93 monoclonal antibodies in a xenograft model of non‑small cell lung cancer

  • Authors:
    • Weiwei Liu
    • Chao Zhang
    • Hui Cao
    • Dai Shi
    • Shanshan Zhao
    • Ting Liang
    • Guihua Hou
  • View Affiliations

  • Published online on: November 1, 2019     https://doi.org/10.3892/ol.2019.11036
  • Pages: 6413-6422
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung cancer, especially non‑small cell lung cancer (NSCLC), is the most common malignant tumor associated with poor prognosis. Angiogenesis plays a vital role in NSCLC, and could be used in tumor staging and therapy evaluation. CD93 (C1q receptor) is reportedly a key regulator of tumor angiogenesis. In the present study, the efficacy and specificity of a 125I‑labeled CD93‑specific monoclonal antibody (125I‑anti‑CD93 mAb) in detecting NSCLC xenografts were analyzed, and the association between CD93 expression and 125I‑anti‑CD93 mAb uptake by tumors was evaluated. The targeting ability of 125I‑anti‑CD93 mAb enabled its rapid, continuous and highly specific accumulation in CD93‑expressing tumors in vivo. These results revealed the potential applicability of 125I‑anti‑CD93 mAb for non‑invasive imaging diagnosis of CD93‑positive NSCLC.
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December-2019
Volume 18 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu W, Zhang C, Cao H, Shi D, Zhao S, Liang T and Hou G: Radioimmunoimaging of 125I‑labeled anti‑CD93 monoclonal antibodies in a xenograft model of non‑small cell lung cancer. Oncol Lett 18: 6413-6422, 2019.
APA
Liu, W., Zhang, C., Cao, H., Shi, D., Zhao, S., Liang, T., & Hou, G. (2019). Radioimmunoimaging of 125I‑labeled anti‑CD93 monoclonal antibodies in a xenograft model of non‑small cell lung cancer. Oncology Letters, 18, 6413-6422. https://doi.org/10.3892/ol.2019.11036
MLA
Liu, W., Zhang, C., Cao, H., Shi, D., Zhao, S., Liang, T., Hou, G."Radioimmunoimaging of 125I‑labeled anti‑CD93 monoclonal antibodies in a xenograft model of non‑small cell lung cancer". Oncology Letters 18.6 (2019): 6413-6422.
Chicago
Liu, W., Zhang, C., Cao, H., Shi, D., Zhao, S., Liang, T., Hou, G."Radioimmunoimaging of 125I‑labeled anti‑CD93 monoclonal antibodies in a xenograft model of non‑small cell lung cancer". Oncology Letters 18, no. 6 (2019): 6413-6422. https://doi.org/10.3892/ol.2019.11036