Open Access

Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report

  • Authors:
    • Nobumichi Takeuchi
    • Kumiko Koike
    • Sonomi Yoshida
    • Masayuki Fujiwara
  • View Affiliations

  • Published online on: November 4, 2019     https://doi.org/10.3892/ol.2019.11043
  • Pages: 6469-6474
  • Copyright: © Takeuchi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Recent therapeutic advancements have prolonged the survival duration of patients with metastatic or recurrent colorectal cancer even during salvage treatment. Although treatment with regorafenib and trifluridine/tipiracil combination has exhibited apparent survival benefits, clear and objective evidence of a response to these drugs is scarce. Herein, the present study reports the case of a patient with rectal cancer refractory to multiple surgical interventions and standard chemotherapy. Treatment with regorafenib resulted in immediate improvement of respiratory failure caused by pulmonary lymphangitic carcinomatosis. This improvement persisted for over 3 months and was confirmed by radiology. Our findings suggest that regorafenib can reduce peritumoral edema via its interaction with the vascular endothelial growth factor receptor. Thus, regorafenib functions as a multityrosine kinase inhibitor to alleviate symptoms of lymphangitic carcinomatosis despite the low potency of the drug.
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December-2019
Volume 18 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Takeuchi N, Koike K, Yoshida S and Fujiwara M: Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report. Oncol Lett 18: 6469-6474, 2019.
APA
Takeuchi, N., Koike, K., Yoshida, S., & Fujiwara, M. (2019). Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report. Oncology Letters, 18, 6469-6474. https://doi.org/10.3892/ol.2019.11043
MLA
Takeuchi, N., Koike, K., Yoshida, S., Fujiwara, M."Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report". Oncology Letters 18.6 (2019): 6469-6474.
Chicago
Takeuchi, N., Koike, K., Yoshida, S., Fujiwara, M."Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report". Oncology Letters 18, no. 6 (2019): 6469-6474. https://doi.org/10.3892/ol.2019.11043