Open Access

Correlation between cytotoxicity in cancer cells and free radical‑scavenging activity: In vitro evaluation of 57 medicinal and edible plant extracts

  • Authors:
    • Marei Sammar
    • Basheer Abu‑Farich
    • Ibrahim Rayan
    • Mizied Falah
    • Anwar Rayan
  • View Affiliations

  • Published online on: November 5, 2019     https://doi.org/10.3892/ol.2019.11054
  • Pages: 6563-6571
  • Copyright: © Sammar et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer is a complex interaction among multiple signaling pathways involving a variety of target molecules. Cancer causes morbidity and mortality in millions of people worldwide, and due to its prevalence, the discovery of novel anticancer drugs is urgently required. Nature is considered an important source of the discovery of anticancer treatments, and many of the cytotoxic medicines in clinics today are derived from plants and other natural sources. Reactive oxygen species (ROS) induce a variety of human cancers, and antioxidants or scavengers are used to counteract them. The current study reports on the screening of extracts from 57 plants that are used in the galilee district as a food and/or for traditional medicine. Investigating the free radical scavenging capacity and these plants, and their cytotoxicity, may prove helpful to high‑throughput screening projects that use antioxidants and cytotoxic natural products. The current study assessed the correlation between free radical scavenging and cytotoxicity. Correlational analysis is important for increasing the efficiency of the screening process. In the present study, free radical scavenging was assessed using a DPPH assay, while cytotoxicity was measured using a XTT assay. A total of 9 extracts were indicated to exhibit EC50 values <250 µg/ml, and 4 others exhibited a high antioxidant content, with EC50 values, for free radical scavenging, of <0.5 µg/ml. An in‑depth analysis of the results revealed that the extracts of plants that exhibit an EC50 of free radical scavenging ≤10 µg/ml show a degree of enrichment toward increased cytotoxicity. It is recommended that future studies test the validity of the conclusions of the current study on other cancer cell‑lines, and isolate and identify the bioactive agents that are found in the most cytotoxic extracts of plants.
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December-2019
Volume 18 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Sammar M, Abu‑Farich B, Rayan I, Falah M and Rayan A: Correlation between cytotoxicity in cancer cells and free radical‑scavenging activity: In vitro evaluation of 57 medicinal and edible plant extracts. Oncol Lett 18: 6563-6571, 2019.
APA
Sammar, M., Abu‑Farich, B., Rayan, I., Falah, M., & Rayan, A. (2019). Correlation between cytotoxicity in cancer cells and free radical‑scavenging activity: In vitro evaluation of 57 medicinal and edible plant extracts. Oncology Letters, 18, 6563-6571. https://doi.org/10.3892/ol.2019.11054
MLA
Sammar, M., Abu‑Farich, B., Rayan, I., Falah, M., Rayan, A."Correlation between cytotoxicity in cancer cells and free radical‑scavenging activity: In vitro evaluation of 57 medicinal and edible plant extracts". Oncology Letters 18.6 (2019): 6563-6571.
Chicago
Sammar, M., Abu‑Farich, B., Rayan, I., Falah, M., Rayan, A."Correlation between cytotoxicity in cancer cells and free radical‑scavenging activity: In vitro evaluation of 57 medicinal and edible plant extracts". Oncology Letters 18, no. 6 (2019): 6563-6571. https://doi.org/10.3892/ol.2019.11054