Open Access

Transcriptome changes induced by RUNX3 in cervical cancer cells in vitro

  • Authors:
    • Qian‑Qian Gao
    • Bin Zhou
    • Xiu‑Zhang Yu
    • Zhu Zhang
    • Yan‑Yun Wang
    • Ya‑Ping Song
    • Lin Zhang
    • Hong Luo
    • Ming‑Rong Xi
  • View Affiliations

  • Published online on: November 21, 2019     https://doi.org/10.3892/ol.2019.11128
  • Pages: 651-662
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Runt‑related transcription factor 3 (RUNX3) is a member of Runt domain family that is known to play key roles in various different types of tumor. It was recently demonstrated that RUNX3 may also be associated with cervical cancer. The aim of the present study was to investigate the potential association between transcriptome changes and RUNX3 expression in cervical cancer. A RUNX3 overexpression model was constructed using cervical cancer cell lines by RUNX3 plasmid transfection. It was demonstrated that the upregulated expression of RUNX3 inhibited proliferation of cervical cancer cell lines, particularly SiHa cells, and was associated with the expression of the IL‑6, PTGS2, FOSL1 and TNF genes. In addition, it was revealed that the TNF and FoxO pathways may also be affected by RUNX3. Therefore, the expression of the RUNX3 gene may be involved in the occurrence and progression of cervical cancer.
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January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Gao QQ, Zhou B, Yu XZ, Zhang Z, Wang YY, Song YP, Zhang L, Luo H and Xi MR: Transcriptome changes induced by RUNX3 in cervical cancer cells in vitro. Oncol Lett 19: 651-662, 2020.
APA
Gao, Q., Zhou, B., Yu, X., Zhang, Z., Wang, Y., Song, Y. ... Xi, M. (2020). Transcriptome changes induced by RUNX3 in cervical cancer cells in vitro. Oncology Letters, 19, 651-662. https://doi.org/10.3892/ol.2019.11128
MLA
Gao, Q., Zhou, B., Yu, X., Zhang, Z., Wang, Y., Song, Y., Zhang, L., Luo, H., Xi, M."Transcriptome changes induced by RUNX3 in cervical cancer cells in vitro". Oncology Letters 19.1 (2020): 651-662.
Chicago
Gao, Q., Zhou, B., Yu, X., Zhang, Z., Wang, Y., Song, Y., Zhang, L., Luo, H., Xi, M."Transcriptome changes induced by RUNX3 in cervical cancer cells in vitro". Oncology Letters 19, no. 1 (2020): 651-662. https://doi.org/10.3892/ol.2019.11128