Open Access

Evaluation of azacitidine in patients with transplant‑ineligible myelodysplastic syndromes and acute myeloid leukemia with myelodysplasia‑related changes in a Japanese clinical setting

  • Authors:
    • Aya Nakaya
    • Shinya Fujita
    • Atsushi Satake
    • Takahisa Nakanishi
    • Yoshiko Azuma
    • Yukie Tsubokura
    • Ryo Saito
    • Akiko Konishi
    • Masaaki Hotta
    • Hideaki Yoshimura
    • Kazuyoshi Ishii
    • Tomoki Ito
    • Shosaku Nomura
  • View Affiliations

  • Published online on: December 18, 2019     https://doi.org/10.3892/ol.2019.11225
  • Pages: 1317-1321
  • Copyright: © Nakaya et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Patients with high‑risk myelodysplastic syndromes (MDS) treated with azacitidine (AZA) have exhibited improved overall survival. However, information on AZA in real‑world settings is limited. The present study retrospectively analyzed 85 patients with MDS treated with AZA. Complete response was achieved in 24% of cases and hematologic improvement in 29%. Severe adverse events (grade ≥3) included neutropenia and infection. Multivariate analysis identified higher revised international prognostic scoring system (IPSS‑R) and male sex as significant factors affecting survival. However, the present study did not identify any significant associations between patient characteristics and response to AZA. In conclusion, AZA could produce a hematologic response in ~53% of patients with MDS. Furthermore, IPSS‑R may reflect MDS prognosis. Further studies are required to establish the criteria for identifying patients likely to obtain maximum benefit from AZA treatment.
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February-2020
Volume 19 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Nakaya A, Fujita S, Satake A, Nakanishi T, Azuma Y, Tsubokura Y, Saito R, Konishi A, Hotta M, Yoshimura H, Yoshimura H, et al: Evaluation of azacitidine in patients with transplant‑ineligible myelodysplastic syndromes and acute myeloid leukemia with myelodysplasia‑related changes in a Japanese clinical setting. Oncol Lett 19: 1317-1321, 2020.
APA
Nakaya, A., Fujita, S., Satake, A., Nakanishi, T., Azuma, Y., Tsubokura, Y. ... Nomura, S. (2020). Evaluation of azacitidine in patients with transplant‑ineligible myelodysplastic syndromes and acute myeloid leukemia with myelodysplasia‑related changes in a Japanese clinical setting. Oncology Letters, 19, 1317-1321. https://doi.org/10.3892/ol.2019.11225
MLA
Nakaya, A., Fujita, S., Satake, A., Nakanishi, T., Azuma, Y., Tsubokura, Y., Saito, R., Konishi, A., Hotta, M., Yoshimura, H., Ishii, K., Ito, T., Nomura, S."Evaluation of azacitidine in patients with transplant‑ineligible myelodysplastic syndromes and acute myeloid leukemia with myelodysplasia‑related changes in a Japanese clinical setting". Oncology Letters 19.2 (2020): 1317-1321.
Chicago
Nakaya, A., Fujita, S., Satake, A., Nakanishi, T., Azuma, Y., Tsubokura, Y., Saito, R., Konishi, A., Hotta, M., Yoshimura, H., Ishii, K., Ito, T., Nomura, S."Evaluation of azacitidine in patients with transplant‑ineligible myelodysplastic syndromes and acute myeloid leukemia with myelodysplasia‑related changes in a Japanese clinical setting". Oncology Letters 19, no. 2 (2020): 1317-1321. https://doi.org/10.3892/ol.2019.11225