Open Access

Oncogenic roles of the cholesterol metabolite 25‑hydroxycholesterol in bladder cancer

  • Authors:
    • Chen Wang
    • Haowei He
    • Wennian Fang
  • View Affiliations

  • Published online on: March 27, 2020     https://doi.org/10.3892/ol.2020.11475
  • Pages: 3671-3676
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oxysterols, such as 24S-hydroxycholesterol and 25-hydroxycholesterol are oxidation products of cholesterol generated by enzymatic reactions. The pathological effects of oxysterols have been described in multiple types of cancer, including cancers of the skin, lung, colon, breast and bile ducts. The molecular mechanisms underlying oxysterol‑induced cancer initiation and progression have yet to be completely elucidated, and to the best of our knowledge, no prior data on the role of 24S‑hydroxycholesterol and 25‑hydroxycholesterol in bladder cancer exists. The results of the present study demonstrated that 25‑hydroxycholesterol is increased in bladder cancer tissues, and that it promotes proliferation and the epithelial‑to‑mesenchymal transition in human T24 and RT4 bladder cancer cells. It was also observed that 25‑hydroxycholesterol promotes Adriamycin resistance in T24 and RT4 cells, and that high levels of 25‑hydroxycholesterol in bladder cancer are associated with a poor outcome. Therefore, 25‑hydroxycholesterol, a primary metabolite of cholesterol, may serve an important role in the progression of bladder cancer.
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June-2020
Volume 19 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang C, He H and Fang W: Oncogenic roles of the cholesterol metabolite 25‑hydroxycholesterol in bladder cancer. Oncol Lett 19: 3671-3676, 2020.
APA
Wang, C., He, H., & Fang, W. (2020). Oncogenic roles of the cholesterol metabolite 25‑hydroxycholesterol in bladder cancer. Oncology Letters, 19, 3671-3676. https://doi.org/10.3892/ol.2020.11475
MLA
Wang, C., He, H., Fang, W."Oncogenic roles of the cholesterol metabolite 25‑hydroxycholesterol in bladder cancer". Oncology Letters 19.6 (2020): 3671-3676.
Chicago
Wang, C., He, H., Fang, W."Oncogenic roles of the cholesterol metabolite 25‑hydroxycholesterol in bladder cancer". Oncology Letters 19, no. 6 (2020): 3671-3676. https://doi.org/10.3892/ol.2020.11475