Open Access

Phenotypic screening using large‑scale genomic libraries to identify drug targets for the treatment of cancer (Review)

  • Authors:
    • Mitsuo Sato
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  • Published online on: April 3, 2020     https://doi.org/10.3892/ol.2020.11512
  • Pages: 3617-3626
  • Copyright: © Sato . This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

During malignant progression to overt cancer cells, normal cells accumulate multiple genetic and non‑genetic changes, which result in the acquisition of various oncogenic properties, such as uncontrolled proliferation, drug resistance, invasiveness, anoikis‑resistance, the ability to bypass oncogene‑induced senescence and cancer stemness. To identify potential novel drug targets contributing to these malignant phenotypes, researchers have performed large‑scale genomic screening using various in vitro and in vivo screening models and identified numerous promising cancer drug target genes. However, there are issues with these identified genes, such as low reproducibility between different datasets. In the present study, the recent advances in the functional screening for identification of cancer drug target genes are summarized, and current issues and future perspectives are discussed.
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June-2020
Volume 19 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Sato M: Phenotypic screening using large‑scale genomic libraries to identify drug targets for the treatment of cancer (Review). Oncol Lett 19: 3617-3626, 2020.
APA
Sato, M. (2020). Phenotypic screening using large‑scale genomic libraries to identify drug targets for the treatment of cancer (Review). Oncology Letters, 19, 3617-3626. https://doi.org/10.3892/ol.2020.11512
MLA
Sato, M."Phenotypic screening using large‑scale genomic libraries to identify drug targets for the treatment of cancer (Review)". Oncology Letters 19.6 (2020): 3617-3626.
Chicago
Sato, M."Phenotypic screening using large‑scale genomic libraries to identify drug targets for the treatment of cancer (Review)". Oncology Letters 19, no. 6 (2020): 3617-3626. https://doi.org/10.3892/ol.2020.11512