Open Access

Comprehensive analysis of a long non‑coding RNA‑associated competing endogenous RNA network in glioma

  • Authors:
    • Jie Zhu
    • Han Wang
    • Yue-Qing Huang
    • Wei Song
    • Yi-Fan Li
    • Wen-Jie Wang
    • Zhi-Liang Ding
  • View Affiliations

  • Published online on: July 29, 2020     https://doi.org/10.3892/ol.2020.11924
  • Article Number: 63
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNAs (lncRNAs) can act as competing endogenous RNAs (ceRNAs), interacting with microRNAs (miRNAs) and playing an important role in tumor progression. However, the role of lncRNA‑mediated ceRNAs in glioma remains largely unknown. The present study aimed to identify novel lncRNAs and their associated function in glioma. RNA sequencing and corresponding clinical data from patients with glioma were obtained from The Cancer Genome Atlas. A total of 598 glioma tissues and 5 normal brain tissues were analyzed in the present study. The differentially expressed (DE) lncRNAs, mRNAs and miRNAs were identified using R packages and were used to construct a ceRNA network. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to investigate the biological functions of the DEmRNAs. Kaplan‑Meier curve analysis was performed to investigate the association between DElncRNA expression and patient outcome. A total of 752 DElncRNAs, 2,079 DEmRNAs and 113 DEmiRNAs were identified between glioma and normal tissues. A lncRNA‑miRNA‑mRNA ceRNA network consisting of 61 lncRNAs, 12 miRNAs and 92 mRNAs was constructed. Survival analysis indicated that 36 DElncRNAs, 72 DEmRNAs and 3 DEmiRNAs were associated with overall survival in patients with glioma. The present study identified novel lncRNAs associated with survival prognosis and may facilitate further investigation of lncRNA‑mediated ceRNA regulatory mechanisms in glioma.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhu J, Wang H, Huang Y, Song W, Li Y, Wang W and Ding Z: Comprehensive analysis of a long non‑coding RNA‑associated competing endogenous RNA network in glioma. Oncol Lett 20: 63, 2020.
APA
Zhu, J., Wang, H., Huang, Y., Song, W., Li, Y., Wang, W., & Ding, Z. (2020). Comprehensive analysis of a long non‑coding RNA‑associated competing endogenous RNA network in glioma. Oncology Letters, 20, 63. https://doi.org/10.3892/ol.2020.11924
MLA
Zhu, J., Wang, H., Huang, Y., Song, W., Li, Y., Wang, W., Ding, Z."Comprehensive analysis of a long non‑coding RNA‑associated competing endogenous RNA network in glioma". Oncology Letters 20.4 (2020): 63.
Chicago
Zhu, J., Wang, H., Huang, Y., Song, W., Li, Y., Wang, W., Ding, Z."Comprehensive analysis of a long non‑coding RNA‑associated competing endogenous RNA network in glioma". Oncology Letters 20, no. 4 (2020): 63. https://doi.org/10.3892/ol.2020.11924