Targeting tumor‑associated macrophages in the tumor microenvironment (Review)
- Authors:
- Kaiwen Zhou
- Tan Cheng
- Jinyue Zhan
- Xuan Peng
- Yue Zhang
- Jianpei Wen
- Xiaoman Chen
- Muying Ying
-
Affiliations: Department of Molecular Biology and Biochemistry, Basic Medical College of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Queen Mary School of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, School of Public Health, School of Medicine, Nanchang University, Nanchang, Jiangxi 330006, P.R. China, The Fourth Clinical Medical College, School of Medicine, Nanchang University, Nanchang, Jiangxi 330006, P.R. China - Published online on: September 14, 2020 https://doi.org/10.3892/ol.2020.12097
- Article Number: 234
-
Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Zent CS and Elliott MR: Maxed out macs: Physiologic cell clearance as a function of macrophage phagocytic capacity. FEBS J. 284:1021–1039. 2017. View Article : Google Scholar : PubMed/NCBI | |
Zhang Q, L Y, Bian H, Guo L and Zhu H: Activation of the α7 nicotinic receptor promotes lipopolysaccharide-induced conversion of M1 microglia to M2. Am J Transl Res. 9:971–985. 2017.PubMed/NCBI | |
Yao Y, Xu XH and Jin L: Macrophage Polarization in physiological and pathological pregnancy. Front Immunol. 10:7922019. View Article : Google Scholar : PubMed/NCBI | |
Gordon S: Alternative activation of macrophages. Nat Rev Immunol. 3:23–35. 2003. View Article : Google Scholar : PubMed/NCBI | |
Gensel JC and Zhang B: Macrophage activation and its role in repair and pathology after spinal cord injury. Brain Res. 1619:1–11. 2015. View Article : Google Scholar : PubMed/NCBI | |
Lefèvre L, Lugo-Villarino G, Meunier E, Valentin A, Olagnier D, Authier H, Duval C, Dardenne C, Bernad J, Lemesre JL, et al: The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum. Immunity. 38:1038–1049. 2013. View Article : Google Scholar : PubMed/NCBI | |
Wang LX, Zhang SX, Wu HJ, Rong XL and Guo J: M2b macrophage polarization and its roles in diseases. J Leukoc Biol. 106:345–358. 2019. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Smith W, Hao D, He B and Kong L: M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds. Int Immunopharmacol. 70:459–466. 2019. View Article : Google Scholar : PubMed/NCBI | |
Yang L and Zhang Y: Tumor-associated macrophages: From basic research to clinical application. J Hematol Oncol. 10:582017. View Article : Google Scholar : PubMed/NCBI | |
Ferrante CJ, Pinhal-Enfield G, Elson G, Cronstein BN, Hasko G, Outram S and Leibovich SJ: The adenosine-dependent angiogenic switch of macrophages to an M2-like phenotype is independent of interleukin-4 receptor alpha (IL-4Rα) signaling. Inflammation. 36:921–931. 2013. View Article : Google Scholar : PubMed/NCBI | |
Mills CD, Lenz LL and Harris RA: A breakthrough: Macrophage-directed cancer immunotherapy. Cancer Res. 76:513–516. 2016. View Article : Google Scholar : PubMed/NCBI | |
Herwig MC, Bergstrom C, Wells JR, Höller T and Grossniklaus HE: M2/M1 ratio of tumor associated macrophages and PPAR-gamma expression in uveal melanomas with class 1 and class 2 molecular profiles. Exp Eye Res. 107:52–58. 2013. View Article : Google Scholar : PubMed/NCBI | |
Wang HC, Chen CW, Yang CL, Tsai IM, Hou YC, Chen CJ and Shan YS: Tumor-associated macrophages promote epigenetic silencing of gelsolin through DNA methyltransferase 1 in gastric cancer cells. Cancer Immunol Res. 5:885–897. 2017. View Article : Google Scholar : PubMed/NCBI | |
Sarode P, Zheng X, Giotopoulou GA, Weigert A, Kuenne C, Günther S, Friedrich A, Gattenlöhner S, Stiewe T, Brüne B, et al: Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer. Sci Adv. 6:eaaz61052020. View Article : Google Scholar : PubMed/NCBI | |
Li X, Liu R, Su X, Pan Y, Han X, Shao C and Shi Y: Harnessing tumor-associated macrophages as aids for cancer immunotherapy. Mol Cancer. 18:1772019. View Article : Google Scholar : PubMed/NCBI | |
Larionova I, Cherdyntseva N, Liu T, Patysheva M, Rakina M and Kzhyshkowska J: Interaction of tumor-associated macrophages and cancer chemotherapy. Oncoimmunology. 8:15960042019. View Article : Google Scholar : PubMed/NCBI | |
Lee HW, Choi HJ, Ha SJ, Lee KT and Kwon YG: Recruitment of monocytes/macrophages in different tumor microenvironments. Biochim Biophys Acta. 1835:170–179. 2013.PubMed/NCBI | |
Fantuzzi L, Tagliamonte M, Gauzzi MC and Lopalco L: Dual CCR5/CCR2 targeting: Opportunities for the cure of complex disorders. Cell Mol Life Sci. 76:4869–4886. 2019. View Article : Google Scholar : PubMed/NCBI | |
Vogel DY, Heijnen PD, Breur M, de Vries HE, Tool AT, Amor S and Dijkstra CD: Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation. J Neuroinflammation. 11:232014. View Article : Google Scholar : PubMed/NCBI | |
Byrne SN, Knox MC and Halliday GM: TGFbeta is responsible for skin tumour infiltration by macrophages enabling the tumours to escape immune destruction. Immunol Cell Biol. 86:92–97. 2008. View Article : Google Scholar : PubMed/NCBI | |
Tang M, Liu B, Bu X and Zhao P: Cross-talk between ovarian cancer cells and macrophages through periostin promotes macrophage recruitment. Cancer Sci. 109:1309–1318. 2018. View Article : Google Scholar : PubMed/NCBI | |
Ruffell B, Affara NI and Coussens LM: Differential macrophage programming in the tumor microenvironment. Trends Immunol. 33:119–126. 2012. View Article : Google Scholar : PubMed/NCBI | |
Henze AT and Mazzone M: The impact of hypoxia on tumor- associated macrophages. J Clin Invest. 26:3672–3679. 2016. View Article : Google Scholar | |
Casazza A, Laoui D, Wenes M, Rizzolio S, Bassani N, Mambretti M, Deschoemaeker S, Van Ginderachter JA, Tamagnone L and Mazzone M: Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell. 24:695–709. 2013. View Article : Google Scholar : PubMed/NCBI | |
Clarijs R, Schalkwijk L, Ruiter DJ and de Waal RM: EMAP-II expression is associated with macrophage accumulation in primary uveal melanoma. Invest Ophthalmol Vis Sci. 44:1801–1816. 2003. View Article : Google Scholar : PubMed/NCBI | |
Huber R, Meier B, Otsuka A, Fenini G, Satoh T, Gehrke S, Widmer D, Levesque MP, Mangana J, Kerl K, et al: Tumour hypoxia promotes melanoma growth and metastasis via high mobility group box-1 and M2-like macrophages. Sci Rep. 6:299142016. View Article : Google Scholar : PubMed/NCBI | |
Tang C, Liu T, Wang K, Wang X, Xu S, He D and Zeng J: Transcriptional regulation of FoxM1 by HIF-1α mediates hypoxia-induced EMT in prostate cancer. Oncol Rep. 42:1307–1318. 2019.PubMed/NCBI | |
Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, et al: Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 19:715–727. 2011. View Article : Google Scholar : PubMed/NCBI | |
Kessenbrock K, Plaks V and Werb Z: Matrix metalloproteinases: Regulators of the tumor microenvironment. Cell. 141:52–67. 2010. View Article : Google Scholar : PubMed/NCBI | |
Arendt LM, McCready J, Keller PJ, Baker DD, Naber SP, Seewaldt V and Kuperwasser C: Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis. Cancer Res. 73:6080–6093. 2013. View Article : Google Scholar : PubMed/NCBI | |
Hao J, Yan F, Zhang Y, Triplett A, Zhang Y, Schultz DA, Sun Y, Zeng J, Silverstein KAT, Zheng Q, et al: Expression of adipocyte/macrophage fatty acid binding protein in tumor associated macrophages promotes breast cancer progression. Cancer Res. 78:2343–2355. 2018. View Article : Google Scholar : PubMed/NCBI | |
Komohara Y and Takeya M: CAFs and TAMs: Maestros of the tumour microenvironment. J Pathol. 241:313–315. 2017. View Article : Google Scholar : PubMed/NCBI | |
Miyake M, Hori S, Morizawa Y, Tatsumi Y, Nakai Y, Anai S, Torimoto K, Aoki K, Tanaka N, Shimada K, et al: CXCL1-mediated interaction of cancer cells with tumor-associated macrophages and cancer-associated fibroblasts promotes tumor progression in human bladder cancer. Neoplasia. 18:636–646. 2016. View Article : Google Scholar : PubMed/NCBI | |
Wan S, Zhao E, Kryczek I, Vatan L, Sadovskaya A, Ludema G, Simeone DM, Zou W and Welling TH: Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology. 147:1393–1404. 2014. View Article : Google Scholar : PubMed/NCBI | |
Yi L, Xiao H, Xu M, Ye X, Hu J, Li F, Li M, Luo C, Yu S, Bian X and Feng H: Glioma-initiating cells: A predominant role in microglia/macrophages tropism to glioma. J Neuroimmunol. 232:75–82. 2011. View Article : Google Scholar : PubMed/NCBI | |
Biswas SK and Mantovani A: Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm. Nat Immunol. 11:889–896. 2010. View Article : Google Scholar : PubMed/NCBI | |
Murray PJ: Macrophage polarization. Annu Rev Physiol. 79:541–566. 2017. View Article : Google Scholar : PubMed/NCBI | |
Chen JJ, Yao PL, Yuan A, Hong TM, Shun CT, Kuo ML, Lee YC and Yang PC: Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: Its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer. Clin Cancer Res. 9:729–737. 2003.PubMed/NCBI | |
Noy R and Pollard JW: Tumor-associated macrophages: From mechanisms to therapy. Immunity. 41:49–61. 2014. View Article : Google Scholar : PubMed/NCBI | |
Liu YC, Zou XB, Chai YF and Yao YM: Macrophage polarization in inflammatory diseases. Int J Biol Sci. 10:520–529. 2014. View Article : Google Scholar : PubMed/NCBI | |
Li X, Luo H, Ye Y, Chen X, Zou Y, Duan J and Xiang D: β-glucan, a dectin-1 ligand, promotes macrophage M1 polarization via NF-κB/autophagy pathway. Int J Oncol. 54:271–282. 2019.PubMed/NCBI | |
Su S, Liu Q, Chen J, Chen J, Chen F, He C, Huang D, Wu W, Lin L, Huang W, et al: A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell. 25:605–620. 2014. View Article : Google Scholar : PubMed/NCBI | |
Pan Z, Tian Y, Niu G and Cao C: Role of microRNAs in remodeling the tumor microenvironment. Int J Oncol. 56:407–416. 2020.PubMed/NCBI | |
Peng D, Kryczek I, Nagarsheth N, Zhao L, Wei S, Wang W, Sun Y, Zhao E, Vatan L, Szeliga W, et al: Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature. 527:249–253. 2015. View Article : Google Scholar : PubMed/NCBI | |
Lawrence T and Natoli G: Transcriptional regulation of macrophage polarization: Enabling diversity with identity. Nat Rev Immunol. 11:750–761. 2011. View Article : Google Scholar : PubMed/NCBI | |
Heusinkveld M and van der Burg SH: Identification and manipulation of tumor associated macrophages in human cancers. J Transl Med. 9:2162011. View Article : Google Scholar : PubMed/NCBI | |
Rolny C, Mazzone M, Tugues S, Laoui D, Johansson I, Coulon C, Squadrito ML, Segura I, Li X, Knevels E, et al: HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell. 19:31–44. 2011. View Article : Google Scholar : PubMed/NCBI | |
Jiang S, Yang Y, Fang M, Li X, Yuan X and Yuan J: Co-evolution of tumor-associated macrophages and tumor neo-vessels during cervical cancer invasion. Oncol Lett. 12:2625–2631. 2016. View Article : Google Scholar : PubMed/NCBI | |
Wyckoff JB, Wang Y, Lin EY, Li JF, Goswami S, Stanley ER, Segall JE, Pollard JW and Condeelis J: Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res. 67:2649–2656. 2007. View Article : Google Scholar : PubMed/NCBI | |
Caux C, Ramos RN, Prendergast GC, Bendriss-Vermare N and Ménétrier-Caux C: A Milestone review on how macrophages affect tumor growth. Cancer Res. 76:6439–6442. 2016. View Article : Google Scholar : PubMed/NCBI | |
Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z and Bergers G: HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 13:206–220. 2008. View Article : Google Scholar : PubMed/NCBI | |
Stockmann C, Doedens A, Weidemann A, Zhang N, Takeda N, Greenberg JI, Cheresh DA and Johnson RS: Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature. 456:814–818. 2008. View Article : Google Scholar : PubMed/NCBI | |
Lin L, Chen YS, Yao YD, Chen JQ, Chen JN, Huang SY, Zeng YJ, Yao HR, Zeng SH, Fu YS and Song EW: CCL18 from tumor-associated macrophages promotes angiogenesis in breast cancer. Oncotarget. 6:34758–34773. 2015. View Article : Google Scholar : PubMed/NCBI | |
Saharinen P, Bry M and Alitalo K: How do angiopoietins Tie with vascular endothelial growth factors? Curr Opin Hematol. 17:198–205. 2010.PubMed/NCBI | |
Chen Y, Song Y, Du W, Gong L, Chang H and Zou Z: Tumor-associated macrophages: An accomplice in solid tumor progression. J Biomed Sci. 26:782019. View Article : Google Scholar : PubMed/NCBI | |
Mazzieri R, Pucci F, Moi D, Zonari E, Ranghetti A, Berti A, Politi LS, Gentner B, Brown JL, Naldini L and De Palma M: Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Cancer Cell. 19:512–526. 2011. View Article : Google Scholar : PubMed/NCBI | |
Dirkx AE, Oude Egbrink MG, Wagstaff J and Griffioen AW: Monocyte/macrophage infiltration in tumors: Modulators of angiogenesis. J Leukoc Biol. 80:1183–1196. 2006. View Article : Google Scholar : PubMed/NCBI | |
Chaffer CL and Weinberg RA: A perspective on cancer cell metastasis. Science. 331:1559–1564. 2011. View Article : Google Scholar : PubMed/NCBI | |
Wyckoff J, Wang W, Lin EY, Wang Y, Pixley F, Stanley ER, Graf T, Pollard JW, Segall J and Condeelis J: A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res. 64:7022–7029. 2004. View Article : Google Scholar : PubMed/NCBI | |
Gocheva V, Wang HW, Gadea BB, Shree T, Hunter KE, Garfall AL, Berman T and Joyce JA: IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev. 24:241–255. 2010. View Article : Google Scholar : PubMed/NCBI | |
DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N and Coussens LM: CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell. 16:91–102. 2009. View Article : Google Scholar : PubMed/NCBI | |
Hernandez L, Smirnova T, Kedrin D, Wyckoff J, Zhu L, Stanley ER, Cox D, Muller WJ, Pollard JW, Van Rooijen N and Segall JE: The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12. Cancer Res. 69:3221–3227. 2009. View Article : Google Scholar : PubMed/NCBI | |
Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL and Karin M: Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature. 457:102–106. 2009. View Article : Google Scholar : PubMed/NCBI | |
Yan D, Wang HW, Bowman RL and Joyce JA: STAT3 and STAT6 signaling pathways synergize to promote cathepsin secretion from macrophages via IRE1α activation. Cell Rep. 16:2914–2927. 2016. View Article : Google Scholar : PubMed/NCBI | |
Quintero-Fabián S, Arreola R, Becerril-Villanueva E, Torres-Romero JC, Arana-Argáez V, Lara-Riegos J, Ramírez-Camacho MA and Alvarez-Sánchez ME: Role of matrix metalloproteinases in angiogenesis and cancer. Front Oncol. 9:13702019. View Article : Google Scholar : PubMed/NCBI | |
Jiang D, Liang J and Noble PW: Hyaluronan as an immune regulator in human diseases. Physiol Rev. 91:221–264. 2011. View Article : Google Scholar : PubMed/NCBI | |
Wang N, Liu W, Zheng Y, Wang S, Yang B, Li M, Song J, Zhang F, Zhang X, Wang Q and Wang Z: CXCL1 derived from tumor-associated macrophages promotes breast cancer metastasis via activating NF-κB/SOX4 signaling. Cell Death Dis. 9:8802018. View Article : Google Scholar : PubMed/NCBI | |
Izumi K and Mizokami A: Suppressive role of androgen/androgen receptor signaling via chemokines on prostate cancer cells. J Clin Med. 8:3542019. View Article : Google Scholar | |
Wang D, Sun H, Wei J, Cen B and DuBois RN: CXCL1 is critical for premetastatic niche formation and metastasis in colorectal cancer. Cancer Res. 13:3655–3665. 2017. View Article : Google Scholar | |
Kawano M, Mabuchi S, Matsumoto Y, Sasano T, Takahashi R, Kuroda H, Kozasa K, Hashimoto K, Isobe A, Sawada K, et al: The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer. Sci Rep. 5:182172015. View Article : Google Scholar : PubMed/NCBI | |
Rőszer T: Understanding the mysterious M2 macrophage through activation markers and effector mechanisms. Mediators Inflamm. 2015:8164602015. View Article : Google Scholar : PubMed/NCBI | |
Okeke EB and Uzonna JE: The pivotal role of regulatory T cells in the regulation of innate immune cells. Front Immunol. 10:6802019. View Article : Google Scholar : PubMed/NCBI | |
Hoves S, Ooi CH, Wolter C, Sade H, Bissinger S, Schmittnaegel M, Ast O, Giusti AM, Wartha K, Runza V, et al: Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity. J Exp Med. 215:859–876. 2018. View Article : Google Scholar : PubMed/NCBI | |
Ma X, Yan W, Zheng H, Du Q, Zhang L, Ban Y, Li N and Wei F: Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells 4. F1000 Faculty Rev-1465. 2015. | |
Kanamori M, Nakatsukasa H, Okada M, Lu Q and Yoshimura A: Induced regulatory T Cells: Their development, stability, and applications. Trends Immunol. 37:803–811. 2016. View Article : Google Scholar : PubMed/NCBI | |
Chanmee T, Ontong P, Konno K and Itano N: Tumor-associated macrophages as major players in the tumor microenvironment. Cancers (Basel). 6:1670–1690. 2014. View Article : Google Scholar : PubMed/NCBI | |
Zhang J, Shi Z, Xu X, Yu Z and Mi J: The influence of microenvironment on tumor immunotherapy. FEBS J. 286:4160–4175. 2019. View Article : Google Scholar : PubMed/NCBI | |
Czystowska-Kuzmicz M, Sosnowska A, Nowis D, Ramji K, Szajnik M, Chlebowska-Tuz J, Wolinska E, Gaj P, Grazul M, Pilch Z, et al: Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma. Nat Commun. 10:30002019. View Article : Google Scholar : PubMed/NCBI | |
Pathria P, Louis TL and Varner JA: Targeting tumor-associated macrophages in cancer. Trends Immunol. 40:310–327. 2019. View Article : Google Scholar : PubMed/NCBI | |
Zhang D, Shi R, Xiang W, Kang X, Tang B, Li C, Gao L, Zhang X, Zhang L, Dai R and Miao H: The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages. Signal Transduct Target Ther. 5:242020. View Article : Google Scholar : PubMed/NCBI | |
Vinogradov S, Warren G and Wei X: Macrophages associated with tumors as potential targets and therapeutic intermediate. Nanomedicine (Lond). 9:695–707. 2014. View Article : Google Scholar : PubMed/NCBI | |
Nywening TM, Belt BA, Cullinan DR, Panni RZ, Han BJ, Sanford DE, Jacobs RC, Ye J, Patel AA, Gillanders WE, et al: Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma. Gut. 67:1112–1123. 2018. View Article : Google Scholar : PubMed/NCBI | |
Lee C, Jeong H, Bae Y, Shin K, Kang S, Kim H, Oh J and Bae H: Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide. J Immunother Cancer. 7:1472019. View Article : Google Scholar : PubMed/NCBI | |
Andersen MN, Etzerodt A, Graversen JH, Holthof LC, Moestrup SK, Hokland M and Møller HJ: STAT3 inhibition specifically in human monocytes and macrophages by CD163-targeted corosolic acid-containing liposomes. Cancer Immunol Immunother. 68:489–502. 2019. View Article : Google Scholar : PubMed/NCBI | |
Wanderley CW, Colón DF, Luiz JPM, Oliveira FF, Viacava PR, Leite CA, Pereira JA, Silva CM, Silva CR, Silva RL, et al: Paclitaxel reduces tumor growth by reprogramming tumor-associated macrophages to an M1 profile in a TLR4-dependent manner. Cancer Res. 78:5891–5900. 2018.PubMed/NCBI | |
Locatelli SL, Careddu G, Serio S, Consonni FM, Maeda A, Viswanadha S, Vakkalanka S, Castagna L, Santoro A, Allavena P, et al: Targeting cancer cells and tumor microenvironment in preclinical and clinical models of Hodgkin lymphoma using the dual PI3Kδ/γ inhibitor RP6530. Clin Cancer Res. 25:1098–1112. 2019. View Article : Google Scholar : PubMed/NCBI | |
Tan HY, Wang N, Man K, Tsao SW, Che CM and Feng Y: Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin. Cell Death Dis. 6:e19422015. View Article : Google Scholar : PubMed/NCBI | |
Medler TR, Murugan D, Horton W, Kumar S, Cotechini T, Forsyth AM, Leyshock P, Leitenberger JJ, Kulesz-Martin M, Margolin AA, et al: Complement C5a fosters squamous carcinogenesis and limits t cell response to chemotherapy. Cancer Cell. 34:561–578.e6. 2018. View Article : Google Scholar : PubMed/NCBI | |
Guerriero JL, Sotayo A, Ponichtera HE, Castrillon JA, Pourzia AL, Schad S, Johnson SF, Carrasco RD, Lazo S, Bronson RT, et al: Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages. Nature. 543:428–432. 2017. View Article : Google Scholar : PubMed/NCBI | |
Zhang W, Wang M, Tang W, Wen R, Zhou S, Lee C, Wang H, Jiang W, Delahunty IM, Zhen Z, et al: Nanoparticle-laden macrophages for tumor-tropic drug delivery. Adv Mater. 30:e18055572018. View Article : Google Scholar : PubMed/NCBI | |
Choi J, Kim HY, Ju EJ, Jung J, Park J, Chung HK, Lee JS, Lee JS, Park HJ, Song SY, et al: Use of macrophages to deliver therapeutic and imaging contrast agents to tumors. Biomaterials. 33:4195–4203. 2012. View Article : Google Scholar : PubMed/NCBI | |
Opperman KS, Vandyke K, Clark KC, Coulter EA, Hewett DR, Mrozik KM, Schwarz N, Evdokiou A, Croucher PI, Psaltis PJ, et al: Clodronate-liposome mediated macrophage depletion abrogates multiple myeloma tumor establishment in vivo. Neoplasia. 21:777–787. 2019. View Article : Google Scholar : PubMed/NCBI | |
Zhang F, Parayath NN, Ene CI, Stephan SB, Koehne AL, Coon ME, Holland EC and Stephan MT: Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers. Nat Commun. 10:39742019. View Article : Google Scholar : PubMed/NCBI | |
Buhtoiarov IN, Sondel PM, Wigginton JM, Buhtoiarova TN, Yanke EM, Mahvi DA and Rakhmilevich AL: Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages. Immunology. 132:226–239. 2011. View Article : Google Scholar : PubMed/NCBI | |
Di Caro G, Cortese N, Castino GF, Grizzi F, Gavazzi F, Ridolfi C, Capretti G, Mineri R, Todoric J, Zerbi A, et al: Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy. Gut. 65:1710–1720. 2016. View Article : Google Scholar : PubMed/NCBI |