Serpin peptidase inhibitor clade A member 1‑overexpression in gastric cancer promotes tumor progression in vitro and is associated with poor prognosis
- Authors:
- Longchang Jiang
- Liangbiao George Hu
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Affiliations: Translational Safety and Bioanalytical Sciences, Amgen Research, Amgen Asia Research and Development Center, Shanghai 201210, P.R. China - Published online on: September 23, 2020 https://doi.org/10.3892/ol.2020.12141
- Article Number: 278
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Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI | |
Ben Kridis W, Marrekchi G, Mzali R, Daoud J and Khanfir A: Prognostic factors in metastatic gastric carcinoma. Exp Oncol. 41:173–175. 2019.PubMed/NCBI | |
Matsuoka T and Yashiro M: Biomarkers of gastric cancer: Current topics and future perspective. World J Gastroentero. 24:2818–2832. 2018. | |
Chia NY and Tan P: Molecular classification of gastric cancer. Ann Oncol. 27:763–769. 2016.PubMed/NCBI | |
Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013.PubMed/NCBI | |
Chen K, Yang D, Li X, Sun B, Song F, Cao W, Brat DJ, Gao Z, Li H, Liang H, et al: Mutational landscape of gastric adenocarcinoma in Chinese: Implications for prognosis and therapy. Proc Natl Acad Sci USA. 112:1107–1112. 2015.PubMed/NCBI | |
Boku N: HER2-positive gastric cancer. Gastric Cancer. 17:1–12. 2014.PubMed/NCBI | |
Oh DY and Bang YJ: HER2-targeted therapies-a role beyond breast cancer. Nat Rev Clin Oncol. 17:33–48. 2020.PubMed/NCBI | |
Pickup M, Novitskiy S and Moses HL: The roles of TGFβ in the tumour microenvironment. Nat Rev Cancer. 13:788–799. 2013.PubMed/NCBI | |
Batlle E and Massagué J: Transforming growth factor-β signaling in immunity and cancer. Immunity. 50:924–940. 2019.PubMed/NCBI | |
Zhao M, Mishra L and Deng CX: The role of TGF-β/SMAD4 signaling in cancer. Int J Biol Sci. 14:111–123. 2018.PubMed/NCBI | |
Vincent T, Neve EP, Johnson JR, Kukalev A, Rojo F, Albanell J, Pietras K, Virtanen I, Philipson L, Leopold PL, et al: A SNAIL1- SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol. 11:943–950. 2009.PubMed/NCBI | |
Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF and Goodall GJ: A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 68:7846–7854. 2008.PubMed/NCBI | |
Thuault S, Valcourt U, Petersen M, Manfioletti G, Heldin CH and Moustakas A: Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J Cell Biol. 174:175–183. 2006.PubMed/NCBI | |
Zhang H, Liu L, Wang Y, Zhao G, Xie R, Liu C, Xiao X, Wu K, Nie Y, Zhang H and Fan D: KLF8 involves in TGF-beta-induced EMT and promotes invasion and migration in gastric cancer cells. J Cancer Res Clin Oncol. 139:1033–1042. 2013.PubMed/NCBI | |
Hawinkels LJ, Verspaget HW, van Duijn W, van der Zon JM, Zuidwijk K, Kubben FJ, Verheijen JH, Hommes DW, Lamers CB and Sier CF: Tissue level, activation and cellular localisation of TGF-beta1 and association with survival in gastric cancer patients. Br J Cancer. 97:398–404. 2007.PubMed/NCBI | |
Normandin K, Péant B, Le Page C, de Ladurantaye M, Ouellet V, Tonin PN, Provencher DM and Mes-Masson AM: Protease inhibitor SERPINA1 expression in epithelial ovarian cancer. Clin Exp Metastas. 27:55–69. 2010. | |
Kwon CH, Park HJ, Choi JH, Lee JR, Kim HK, Jo HJ, Kim HS, Oh N, Song GA and Park DY: Snail and serpinA1 promote tumor progression and predict prognosis in colorectal cancer. Oncotarget. 6:20312–20326. 2015.PubMed/NCBI | |
Ercetin E, Richtmann S, Delgado BM, Gomez-Mariano G, Wrenger S, Korenbaum E, Liu B, DeLuca D, Kuhnel MP, Jonigk D, et al: Clinical significance of SERPINA1 gene and its encoded alpha1-antitrypsin protein in NSCLC. Cancers (Basel). 11:13062019. | |
Janciauskiene S: Conformational properties of serine proteinase inhibitors (serpins) confer multiple pathophysiological roles. Biochim Biophys Acta. 1535:221–235. 2001.PubMed/NCBI | |
Farshchian M, Kivisaari A, Ala-aho R, Riihilä P, Kallajoki M, Grénman R, Peltonen J, Pihlajaniemi T, Heljasvaara R and Kähäri VM: Serpin peptidase inhibitor Clade A member 1 (SerpinA1) is a novel biomarker for progression of cutaneous squamous cell carcinoma. Am J Pathol. 179:1110–1119. 2011.PubMed/NCBI | |
Chan HJ, Li H, Liu Z, Yuan YC, Mortimer J and Chen S: SERPINA1 is a direct estrogen receptor target gene and a predictor of survival in breast cancer patients. Oncotarget. 6:25815–25827. 2015.PubMed/NCBI | |
Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004.PubMed/NCBI | |
Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45W:W98–W102. 2017. | |
Bass AJ, Thorsson V, Shmulevich I, Reynolds SM, Miller M, Bernard B, Hinoue T, Laird PW, Curtis C, Shen H, et al: Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 513:202–209. 2014.PubMed/NCBI | |
Muzny DM, Bainbridge MN, Chang K, Dinh HH, Drummond JA, Fowler G, Kovar CL, Lewis LR, Morgan MB, Newsham IF, et al: Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487:330–337. 2012.PubMed/NCBI | |
Kim J, Bowlby R, Mungall AJ, Robertson AG, Odze RD, Cherniack AD, Shih J, Pedamallu CS, Cibulskis C, Dunford A, et al: Integrated genomic characterization of oesophageal carcinoma. Nature. 541:169–174. 2017.PubMed/NCBI | |
Raphael BJ, Hruban RH, Aguirre AJ, Moffitt RA, Yeh JJ, Stewart C, Robertson AG, Cherniack AD, Gupta M, Getz G, et al: Integrated genomic characterization of pancreatic ductal adenocarcinoma. Cancer Cell. 32:185–203.e13. 2017.PubMed/NCBI | |
Carithers LJ, Ardlie K, Barcus M, Branton PA, Britton A, Buia SA, Compton CC, DeLuca DS, Peter-Demchok J, Gelfand ET, et al: A novel approach to high-quality postmortem tissue procurement: The GTEx project. Biopreserv Biobank. 13:311–319. 2015.PubMed/NCBI | |
Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR and Winchester DP: The eighth edition AJCC cancer staging manual: Continuing to build a bridge from a population-based to a more ‘personalized’ approach to cancer staging. CA Cancer J Clin. 67:93–99. 2017.PubMed/NCBI | |
Szasz AM, Lanczky A, Nagy A, Forster S, Hark K, Green JE, Boussioutas A, Busuttil R, Szabo A and Gyorffy B: Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients. Oncotarget. 7:49322–49333. 2016.PubMed/NCBI | |
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005.PubMed/NCBI | |
Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012.PubMed/NCBI | |
Kramer A, Green J, Pollard J Jr and Tugendreich S: Causal analysis approaches in ingenuity pathway analysis. Bioinformatics. 30:523–530. 2014.PubMed/NCBI | |
Oughtred R, Stark C, Breitkreutz BJ, Rust J, Boucher L, Chang C, Kolas N, O'Donnell L, Leung G, McAdam R, et al: The BioGRID interaction database: 2019 update. Nucleic Acids Res. 47D:D529–D541. 2019. | |
Orii N and Ganapathiraju MK: Wiki-pi: A web-server of annotated human protein-protein interactions to aid in discovery of protein function. PLoS One. 7:e490292012.PubMed/NCBI | |
Kim B: Western blot techniques. Methods Mol Biol. 1606:133–139. 2017.PubMed/NCBI | |
Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI | |
Skrzypczak M, Goryca K, Rubel T, Paziewska A, Mikula M, Jarosz D, Pachlewski J, Oledzki J and Ostrowski J: Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability. PLoS One. 5:e130912010.PubMed/NCBI | |
Sabates-Bellver J, Van der Flier LG, de Palo M, Cattaneo E, Maake C, Rehrauer H, Laczko E, Kurowski MA, Bujnicki JM, Menigatti M, et al: Transcriptome profile of human colorectal adenomas. Mol Cancer Res. 5:1263–1275. 2007.PubMed/NCBI | |
Kimchi ET, Posner MC, Park JO, Darga TE, Kocherginsky M, Karrison T, Hart J, Smith KD, Mezhir JJ, Weichselbaum RR and Khodarev NN: Progression of Barrett's metaplasia to adenocarcinoma is associated with the suppression of the transcriptional programs of epidermal differentiation. Cancer Res. 65:3146–3154. 2005.PubMed/NCBI | |
Kim SM, Park YY, Park ES, Cho JY, Izzo JG, Zhang D, Kim SB, Lee JH, Bhutani MS, Swisher SG, et al: Prognostic biomarkers for esophageal adenocarcinoma identified by analysis of tumor transcriptome. PLoS One. 5:e150742010.PubMed/NCBI | |
Wang Q, Wen YG, Li DP, Xia J, Zhou CZ, Yan DW, Tang HM and Peng ZH: Upregulated INHBA expression is associated with poor survival in gastric cancer. Med Oncol. 29:77–83. 2012.PubMed/NCBI | |
Badea L, Herlea V, Dima SO, Dumitrascu T and Popescu I: Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia. Hepatogastroenterology. 55:2016–2027. 2008.PubMed/NCBI | |
Logsdon CD, Simeone DM, Binkley C, Arumugam T, Greenson JK, Giordano TJ, Misek DE, Kuick R and Hanash S: Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res. 63:2649–2657. 2003.PubMed/NCBI | |
Liberzon A, Birger C, Thorvaldsdottir H, Ghandi M, Mesirov JP and Tamayo P: The molecular signatures database (MSigDB) hallmark gene set collection. Cell Syst. 1:417–425. 2015.PubMed/NCBI | |
Faulstich H, Zobeley S, Rinnerthaler G and Small JV: Fluorescent phallotoxins as probes for filamentous actin. J Muscle Res Cell Motil. 9:370–383. 1988.PubMed/NCBI | |
Deckers M, van Dinther M, Buijs J, Que I, Lowik C, van der Pluijm G and ten Dijke P: The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res. 66:2202–2209. 2006.PubMed/NCBI | |
Huang G, Du MY, Zhu H, Zhang N, Lu ZW, Qian LX, Zhang W, Tian X, He X and Yin L: MiRNA-34a reversed TGF-β-induced epithelial-mesenchymal transition via suppression of SMAD4 in NPC cells. Biomed Pharmacother. 106:217–224. 2018.PubMed/NCBI | |
Yu C, Liu Y, Huang D, Dai Y, Cai G, Sun J, Xu T, Tian Y and Zhang X: TGF-β1 mediates epithelial to mesenchymal transition via the TGF-β/Smad pathway in squamous cell carcinoma of the head and neck. Oncol Rep. 25:1581–1587. 2011.PubMed/NCBI | |
Levy L and Hill CS: Smad4 dependency defines two classes of transforming growth factor β (TGF-β) target genes and distinguishes TGF-β-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol Cell Biol. 25:8108–8125. 2005.PubMed/NCBI | |
Bray F, Colombet M, Mery L, Piñeros M, Znaor A, Zanetti R and Ferlay J: Cancer Incidence in Five Continents. XI. International Agency for Research on Cancer; Lyon: 2017, http://ci5.iarc.frJuly 20–2020 | |
Curado MP, Edwards B, Shin HR, Storm H, Ferlay J, Heanue M and Boyle P: Cancer Incidence in Five Continents. IX. International Agency for Research on Cancer; Lyon: 2007, http://ci5.iarc.frJuly 20–2020 | |
Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW and Vasiliou V: Update of the human and mouse SERPIN gene superfamily. Hum Genomics. 7:222013.PubMed/NCBI | |
El-Akawi ZJ, Al-Hindawi FK and Bashir NA: Alpha-1 antitrypsin (alpha1-AT) plasma levels in lung, prostate and breast cancer patients. Neuro Endocrinol Lett. 29:482–484. 2008.PubMed/NCBI | |
Yang J, Xiong X, Wang X, Guo B, He K and Huang C: Identification of peptide regions of SERPINA1 and ENOSF1 and their protein expression as potential serum biomarkers for gastric cancer. Tumour Biol. 36:5109–5118. 2015.PubMed/NCBI | |
Kwon CH, Park HJ, Lee JR, Kim HK, Jeon TY, Jo HJ, Kim DH, Kim GH and Park DY: Serpin peptidase inhibitor clade A member 1 is a biomarker of poor prognosis in gastric cancer. Br J Cancer. 111:1993–2002. 2014.PubMed/NCBI | |
Pollard TD: The cytoskeleton, cellular motility and the reductionist agenda. Nature. 422:741–745. 2003.PubMed/NCBI | |
Byon CH, Hardy RW, Ren C, Ponnazhagan S, Welch DR, McDonald JM and Chen Y: Free fatty acids enhance breast cancer cell migration through plasminogen activator inhibitor-1 and SMAD4. Lab Invest. 89:1221–1228. 2009.PubMed/NCBI | |
Hernanda PY, Chen K, Das AM, Sideras K, Wang W, Li J, Cao W, Bots SJ, Kodach LL, de Man RA, et al: SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma. Oncogene. 34:5055–5068. 2015.PubMed/NCBI | |
Heldin CH, Miyazono K and Ten Dijke P: TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature. 390:465–471. 1997.PubMed/NCBI | |
Komiyama T, Gron H, Pemberton PA and Salvesen GS: Interaction of subtilisins with serpins. Protein Sci. 5:874–882. 1996.PubMed/NCBI | |
Christensson A, Laurell CB and Lilja H: Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors. Eur J Biochem. 194:755–763. 1990.PubMed/NCBI | |
Korkmaz B, Attucci S, Hazouard E, Ferrandiere M, Jourdan ML, Brillard-Bourdet M, Juliano L and Gauthier F: Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates. J Biol Chem. 277:39074–39081. 2002.PubMed/NCBI | |
Taggart C, Cervantes-Laurean D, Kim G, McElvaney NG, Wehr N, Moss J and Levine RL: Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity. J Biol Chem. 275:27258–27265. 2000.PubMed/NCBI | |
Greenblatt EJ, Olzmann JA and Kopito RR: Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum. Nat Struct Mol Biol. 18:1147–1152. 2011.PubMed/NCBI | |
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Heriche JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, et al: Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science. 328:593–599. 2010.PubMed/NCBI | |
Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D and He F: Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. J Proteome Res. 7:3879–3889. 2008.PubMed/NCBI | |
LaLonde DP and Bretscher A: The UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradation. J Biol Chem. 286:4892–4901. 2011.PubMed/NCBI | |
Satoh T, Chen Y, Hu D, Hanashima S, Yamamoto K and Yamaguchi Y: Structural basis for oligosaccharide recognition of misfolded glycoproteins by OS-9 in ER-associated degradation. Mol Cell. 40:905–916. 2010.PubMed/NCBI | |
Christianson JC, Shaler TA, Tyler RE and Kopito RR: OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat Cell Biol. 10:272–282. 2008.PubMed/NCBI | |
Fujimori T, Kamiya Y, Nagata K, Kato K and Hosokawa N: Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsin variant. FEBS J. 280:1563–1575. 2013.PubMed/NCBI | |
Schaafhausen A, Rost S, Oldenburg J and Muller CR: Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. Thromb Haemost. 105:285–294. 2011.PubMed/NCBI | |
Mikami K, Yamaguchi D, Tateno H, Hu D, Qin SY, Kawasaki N, Yamada M, Matsumoto N, Hirabayashi J, Ito Y and Yamamoto K: The sugar-binding ability of human OS-9 and its involvement in ER-associated degradation. Glycobiology. 20:310–321. 2010.PubMed/NCBI | |
Yamaguchi D, Hu D, Matsumoto N and Yamamoto K: Human XTP3-B binds to alpha1-antitrypsin variant null (Hong Kong) via the C-terminal MRH domain in a glycan-dependent manner. Glycobiology. 20:348–355. 2010.PubMed/NCBI | |
Nagasawa K, Higashi T, Hosokawa N, Kaufman RJ and Nagata K: Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation. EMBO Rep. 8:483–489. 2007.PubMed/NCBI | |
Moussavi-Harami SF, Annis DS, Ma W, Berry SM, Coughlin EE, Strotman LN, Maurer LM, Westphall MS, Coon JJ, Mosher DF and Beebe DJ: Characterization of molecules binding to the 70 K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry. J Proteome Res. 12:3393–3404. 2013.PubMed/NCBI | |
Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, Tam S, Zarraga G, Colby G, Baltier K, et al: The BioPlex network: A systematic exploration of the human interactome. Cell. 162:425–440. 2015.PubMed/NCBI | |
Jung CH, Kim YH, Lee K and Im H: Retarded protein folding of the human Z-type α1-antitrypsin variant is suppressed by Cpr2p. Biochem Biophys Res Commun. 445:191–195. 2014.PubMed/NCBI | |
Huang CH, Hsiao HT, Chu YR, Ye Y and Chen X: Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum. J Biol Chem. 288:25330–25339. 2013.PubMed/NCBI | |
Fan W, Cheng J, Zhang S and Liu X: Cloning and functions of the HBxAg-binding protein XBP1. Mol Med Rep. 7:618–622. 2013.PubMed/NCBI | |
Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C, Wang W, Guan W, et al: Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 7:5362011.PubMed/NCBI | |
Feng L, Zhang J, Zhu N, Ding Q, Zhang X, Yu J, Qiang W, Zhang Z, Ma Y, Huang D, et al: Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/α-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy. Autophagy. 13:686–702. 2017.PubMed/NCBI | |
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, et al: Architecture of the human interactome defines protein communities and disease networks. Nature. 545:505–509. 2017.PubMed/NCBI | |
Wen JH, Wen H, Gibson-Corley KN and Glenn KA: FBG1 is the final arbitrator of A1AT-Z degradation. PLoS One. 10:e1355912015. | |
Dersh D, Jones SM, Eletto D, Christianson JC and Argon Y: OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation. Mol Biol Cell. 25:2220–2234. 2014.PubMed/NCBI | |
Khodayari N, Wang RL, Marek G, Krotova K, Kirst M, Liu C, Rouhani F and Brantly M: SVIP regulates Z variant alpha-1 antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78. PLoS One. 12:e1729832017. | |
Xiao Y, Han J, Wang Q, Mao Y, Wei M, Jia W and Wei L: A novel interacting protein SERP1 regulates the N-Linked glycosylation and function of GLP-1 receptor in the liver. J Cell Biochem. 118:3616–3626. 2017.PubMed/NCBI | |
Kadowaki H, Nagai A, Maruyama T, Takami Y, Satrimafitrah P, Kato H, Honda A, Hatta T, Natsume T, Sato T, et al: Pre-emptive quality control protects the ER from protein overload via the proximity of ERAD components and SRP. Cell Rep. 13:944–956. 2015.PubMed/NCBI | |
Pankow S, Bamberger C, Calzolari D, Martinez-Bartolome S, Lavallee-Adam M, Balch WE and Yates JR III: ∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Nature. 528:510–516. 2015.PubMed/NCBI | |
Kadowaki H, Satrimafitrah P, Takami Y and Nishitoh H: Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1. Sci Rep. 8:73172018.PubMed/NCBI | |
Giurato G, Nassa G, Salvati A, Alexandrova E, Rizzo F, Nyman TA, Weisz A and Tarallo R: Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. Sci Data. 5:1800312018.PubMed/NCBI | |
Yu S, Ito S, Wada I and Hosokawa N: ER-resident protein 46 (ERp46) triggers the mannose-trimming activity of ER degradation-enhancing α-mannosidase-like protein 3 (EDEM3). J Biol Chem. 293:10663–10674. 2018.PubMed/NCBI | |
Lamriben L, Oster ME, Tamura T, Tian W, Yang Z, Clausen H and Hebert DN: EDEM1's mannosidase-like domain binds ERAD client proteins in a redox-sensitive manner and possesses catalytic activity. J Biol Chem. 293:13932–13945. 2018.PubMed/NCBI |