Carcinogenic effects of bisphenol A in breast and ovarian cancers (Review)
- Authors:
- Mihai Cristian Dumitrascu
- Cristian Mares
- Razvan-Cosmin Petca
- Florica Sandru
- Razvan-Ionut Popescu
- Claudia Mehedintu
- Aida Petca
-
Affiliations: Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Urology, ‘Prof. Dr. Th. Burghele’ Clinical Hospital, 050659 Bucharest, Romania, Department of Dermatology, Elias Emergency University Hospital, 011461 Bucharest, Romania - Published online on: September 23, 2020 https://doi.org/10.3892/ol.2020.12145
- Article Number: 282
This article is mentioned in:
Abstract
Thompson RC, Swan SH, Moore CJ and vom Saal FS: Our plastic age. Philos Trans R Soc Lond B Biol Sci. 364:1973–1976. 2009.PubMed/NCBI | |
Halden RU: Plastics and health risks. Annu Rev Public Health. 31:179–194. 2010.PubMed/NCBI | |
Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J and Zoeller RT: Executive summary to EDC-2: The endocrine society's second scientific statement on endocrine-disrupting chemicals. Endocr Rev. 36:593–602. 2015.PubMed/NCBI | |
Rodriguez C, Patel AV, Calle EE, Jacob EJ and Thun MJ: Estrogen replacement therapy and ovarian cancer mortality in a large prospective study of US women. JAMA. 285:1460–1465. 2001.PubMed/NCBI | |
Dodds LW and Lawson W: Synthetic estrogenic agents without the phenanthrene nucleus. Nature. 137:9961937. | |
Ding ZM, Jiao XF, Wu D, Zhang JY, Chen F, Wang YS, Huang CJ, Zhang SX, Li X and Huo LJ: Bisphenol AF negatively affects oocyte maturation of mouse in vitro through increasing oxidative stress and DNA damage. Chem Biol Interact. 278:222–229. 2017.PubMed/NCBI | |
Geens T, Goeyens L and Covaci A: Are potential sources for human exposure to bisphenol-A overlooked? Int J Hyg Environ Health. 214:339–347. 2011.PubMed/NCBI | |
Vivacqua A, Recchia AG, Fasanella G, Gabriele S, Carpino A, Rago V, Di Gioia ML, Leggio A, Bonofiglio D, Liguori A, et al: The food contaminants bisphenol A and 4-nonylphenol act as agonists for estrogen receptor alpha in MCF7 breast cancer cells. Endocrine. 22:275–284. 2003.PubMed/NCBI | |
Geens T, Aerts D, Berthot C, Bourguignon JP, Goeyens L, Lecomte P, Maghuin-Rogister G, Pironnet AM, Pussemier L, Scippo ML, et al: A review of dietary and non-dietary exposure to bisphenol-A. Food Chem Toxicol. 50:3725–3740. 2012.PubMed/NCBI | |
Konieczna A, Rutkowska A and Rachoń D: Health risk of exposure to Bisphenol A (BPA). Rocz Panstw Zakl Hig. 66:5–11. 2015.PubMed/NCBI | |
Van Landuyt KL, Nawrot T, Geebelen B, De Munck J, Snauwaert J, Yoshihara K, Scheers H, Godderis L, Hoet P and Van Meerbeek B: How much do resin-based dental materials release? A meta-analytical approach. Dent Mater. 27:723–747. 2011.PubMed/NCBI | |
Oldring PK, Castle L, O'Mahony C and Dixon J: Estimates of dietary exposure to bisphenol A (BPA) from light metal packaging using food consumption and packaging usage data: A refined deterministic approach and a fully probabilistic (FACET) approach. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 31:466–489. 2014.PubMed/NCBI | |
Cao XL, Corriveau J and Popovic S: Bisphenol a in canned food products from canadian markets. J Food Prot. 73:1085–1089. 2010.PubMed/NCBI | |
Hanaoka T, Kawamura N, Hara K and Tsugane S: Urinary bisphenol A and plasma hormone concentrations in male workers exposed to bisphenol A diglycidyl ether and mixed organic solvents. Occup Environ Med. 59:625–628. 2002.PubMed/NCBI | |
Calafat AM, Ye X, Wong LY, Reidy JA and Needham LL: Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003–2004. Environ Health Perspect. 116:39–44. 2008.PubMed/NCBI | |
Erler C and Novak J: Bisphenol a exposure: Human risk and health policy. J Pediatr Nurs. 25:400–407. 2010.PubMed/NCBI | |
Zhang T, Sun H and Kannan K: Blood and urinary bisphenol A concentrations in children, adults, and pregnant women from china: Partitioning between blood and urine and maternal and fetal cord blood. Environ Sci Technol. 47:4686–4694. 2013.PubMed/NCBI | |
Huang RP, Liu ZH, Yin H, Dang Z, Wu PX, Zhu NW and Lin Z: Bisphenol A concentrations in human urine, human intakes across six continents, and annual trends of average intakes in adult and child populations worldwide: A thorough literature review. Sci Total Environ. 626:971–981. 2018.PubMed/NCBI | |
Drozdz K, Wysokinski D, Krupa R and Wozniak K: Bisphenol A-glycidyl methacrylate induces a broad spectrum of DNA damage in human lymphocytes. Arch Toxicol. 85:1453–1461. 2011.PubMed/NCBI | |
Fleisch AF, Sheffield PE, Chinn C, Edelstein BL and Landrigan PJ: Bisphenol A and related compounds in dental materials. Pediatrics. 126:760–768. 2010.PubMed/NCBI | |
Dumitrascu MC, Iliescu M, Petca RC, Sandru F, Mehedintu C, Farcasanu PD, Maru N, Chibelean C and Petca A: The chemical pregnancy. Rev Chim. 70:3818–3823. 2019. | |
Ehrlich S, Williams PL, Missmer SA, Flaws JA, Ye X, Calafat AM, Petrozza JC, Wright D and Hauser R: Urinary bisphenol A concentrations and early reproductive health outcomes among women undergoing IVF. Hum Reprod. 27:3583–3592. 2012.PubMed/NCBI | |
Petca A, Bot M, Petca RC, Mehedintu C, Barac RI, Iliescu M, Maru N and Mastalier B: Chemicals in personal care tied to early puberty in girls. Rev Chim. 70:3206–3209. 2019. | |
Fernández M, Bourguignon N, Lux-Lantos V and Libertun C: Neonatal exposure to bisphenol a and reproductive and endocrine alterations resembling the polycystic ovarian syndrome in adult rats. Environ Health Perspect. 118:1217–1222. 2010.PubMed/NCBI | |
Cobellis L, Colacurci N, Trabucco E, Carpentiero C and Grumetto L: Measurement of bisphenol A and bisphenol B levels in human blood sera from healthy and endometriotic women. Biomed Chromatogr. 23:1186–1190. 2009.PubMed/NCBI | |
Hoepner LA, Whyatt RM, Widen EM, Hassoun A, Oberfield SE, Mueller NT, Diaz D, Calafat AM, Perera FP and Rundle AG: Bisphenol A and Adiposity in an Inner-City Birth Cohort. Environ Health Perspect. 124:1644–1650. 2016.PubMed/NCBI | |
Castoria G, Giovannelli P, Lombardi M, De Rosa C, Giraldi T, de Falco A, Barone MV, Abbondanza C, Migliaccio A and Auricchio F: Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells. Oncogene. 31:4868–4877. 2012.PubMed/NCBI | |
Mares C, Popescu R, Petca A, Maru N, Dogaroiu C and Petca RC: Bisphenol-A and other plastics: Review of endocrine disrupting effects on prostate cancer. Mater Plast. 57:239–252. 2020. | |
Lombardi M, Castoria G, Migliaccio A, Barone MV, Di Stasio R, Ciociola A, Bottero D, Yamaguchi H, Appella E and Auricchio F: Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells. J Cell Biol. 182:327–340. 2008.PubMed/NCBI | |
Varricchio L, Migliaccio A, Castoria G, Yamaguchi H, de Falco A, Di Domenico M, Giovannelli P, Farrar W, Appella E and Auricchio F: Inhibition of estradiol receptor/Src association and cell growth by an estradiol receptor alpha tyrosine-phosphorylated peptide. Mol Cancer Res. 5:1213–1221. 2007.PubMed/NCBI | |
Rodríguez HA, Santambrosio N, Santamaría CG, Muñoz-de-Toro M and Luque EH: Neonatal exposure to bisphenol A reduces the pool of primordial follicles in the rat ovary. Reprod Toxicol. 30:550–557. 2010.PubMed/NCBI | |
Markey CM, Coombs MA, Sonnenschein C and Soto AM: Mammalian development in a changing environment: Exposure to endocrine disruptors reveals the developmental plasticity of steroid-hormone target organs. Evol Dev. 5:67–75. 2003.PubMed/NCBI | |
Hunt PA, Koehler KE, Susiarjo M, Hodges CA, Ilagan A, Voigt RC, Thomas S, Thomas BF and Hassold TJ: Bisphenol a exposure causes meiotic aneuploidy in the female mouse. Curr Biol. 13:546–553. 2003.PubMed/NCBI | |
Mei L, Chen H, Wei DM, Fang F, Liu GJ, Xie HY, Wang X, Zou J, Han X and Feng D: Maintenance chemotherapy for ovarian cancer. Cochrane Database Syst Rev. 9:CD0074142010. | |
Petca A, Petca RC, Zvanca M, Maru N, Mastalier B and Dogaroiu C: Fetal death from ruptured vasa previa: A tragic event in the ultrasonographic era. Rom J Leg Med. 27:43–46. 2019. | |
Momenimovahed Z, Tiznobaik A, Taheri S and Salehiniya H: Ovarian cancer in the world: Epidemiology and risk factors. Int J Womens Health. 11:287–299. 2019.PubMed/NCBI | |
Dekant W and Völkel W: Human exposure to bisphenol A by biomonitoring: Methods, results and assessment of environmental exposures. Toxicol Appl Pharmacol. 228:114–134. 2008.PubMed/NCBI | |
Akahira J, Suzuki T, Ito K, Kaneko C, Darnel AD, Moriya T, Okamura K, Yaegashi N and Sasano H: Differential expression of progesterone receptor isoforms A and B in the normal ovary, and in benign, borderline, and malignant ovarian tumors. Jpn J Cancer Res. 93:807–815. 2002.PubMed/NCBI | |
Newbold RR, Jefferson WN and Padilla-Banks E: Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract. Reprod Toxicol. 24:253–258. 2007.PubMed/NCBI | |
Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjöld M and Gustafsson JA: Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab. 82:4258–4265. 1997.PubMed/NCBI | |
Kuiper GG and Gustafsson JA: The novel estrogen receptor-beta subtype: Potential role in the cell- and promoter-specific actions of estrogens and anti-estrogens. FEBS Lett. 410:87–90. 1997.PubMed/NCBI | |
Pujol P, Rey JM, Nirde P, Roger P, Gastaldi M, Laffargue F, Rochefort H and Maudelonde T: Differential expression of estrogen receptor-α and -β messenger RNAs as a potential marker of ovarian carcinogenesis. Cancer Res. 58:5367–5373. 1998.PubMed/NCBI | |
Bardin A, Hoffmann P, Boulle N, Katsaros D, Vignon F, Pujol P and Lazennec G: Involvement of estrogen receptor beta in ovarian carcinogenesis. Cancer Res. 64:5861–5869. 2004.PubMed/NCBI | |
Hua H, Zhang H, Kong Q and Jiang Y: Mechanisms for estrogen receptor expression in human cancer. Exp Hematol Oncol. 7:242018.PubMed/NCBI | |
Münstedt K, Steen J, Knauf AG, Buch T, von Georgi R and Franke FE: Steroid hormone receptors and long term survival in invasive ovarian cancer. Cancer. 89:1783–1791. 2000.PubMed/NCBI | |
Bai W, Oliveros-Saunders B, Wang Q, Acevedo-Duncan ME and Nicosia SV: Estrogen stimulation of ovarian surface epithelial cell proliferation. In Vitro Cell Dev Biol Anim. 36:657–666. 2000.PubMed/NCBI | |
O'Donnell AJ, Macleod KG, Burns DJ, Smyth JF and Langdon SP: Estrogen receptor-alpha mediates gene expression changes and growth response in ovarian cancer cells exposed to estrogen. Endocr Relat Cancer. 12:851–866. 2005.PubMed/NCBI | |
Riman T, Dickman PW, Nilsson S, Correia N, Nordlinder H, Magnusson CM, Weiderpass E and Persson IR: Hormone replacement therapy and the risk of invasive epithelial ovarian cancer in Swedish women. J Natl Cancer Inst. 94:497–504. 2002.PubMed/NCBI | |
Lacey JV Jr, Mink PJ, Lubin JH, Sherman ME, Troisi R, Hartge P, Schatzkin A and Schairer C: Menopausal hormone replacement therapy and risk of ovarian cancer. JAMA. 288:334–341. 2002.PubMed/NCBI | |
Suzuki A, Sugihara A, Uchida K, Sato T, Ohta Y, Katsu Y, Watanabe H and Iguchi T: Developmental effects of perinatal exposure to bisphenol-A and diethylstilbestrol on reproductive organs in female mice. Reprod Toxicol. 16:107–116. 2002.PubMed/NCBI | |
Ptak A, Wróbel A and Gregoraszczuk EL: Effect of bisphenol-A on the expression of selected genes involved in cell cycle and apoptosis in the OVCAR-3 cell line. Toxicol Lett. 202:30–35. 2011.PubMed/NCBI | |
Ptak A and Gregoraszczuk EL: Bisphenol A induces leptin receptor expression, creating more binding sites for leptin, and activates the JAK/Stat, MAPK/ERK and PI3K/Akt signalling pathways in human ovarian cancer cell. Toxicol Lett. 210:332–337. 2012.PubMed/NCBI | |
Bredhult C, Bäcklin BM and Olovsson M: Effects of some endocrine disruptors on the proliferation and viability of human endometrial endothelial cells in vitro. Reprod Toxicol. 23:550–559. 2007.PubMed/NCBI | |
Hall JM and Korach KS: Endocrine disrupting chemicals promote the growth of ovarian cancer cells via the ER-CXCL12-CXCR4 signaling axis. Mol Carcinog. 52:715–725. 2013.PubMed/NCBI | |
Cavallaro U and Christofori G: Multitasking in tumor progression: Signaling functions of cell adhesion molecules. Ann N Y Acad Sci. 1014:58–66. 2004.PubMed/NCBI | |
Lengyel E: Ovarian cancer development and metastasis. Am J Pathol. 177:1053–1064. 2010.PubMed/NCBI | |
Hazan RB, Phillips GR, Qiao RF, Norton L and Aaronson SA: Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol. 148:779–790. 2000.PubMed/NCBI | |
Hudson LG, Zeineldin R and Stack MS: Phenotypic plasticity of neoplastic ovarian epithelium: Unique cadherin profiles in tumor progression. Clin Exp Metastasis. 25:643–655. 2008.PubMed/NCBI | |
Davidson B, Goldberg I, Gotlieb WH, Kopolovic J, Ben-Baruch G, Nesland JM and Reich R: The prognostic value of metalloproteinases and angiogenic factors in ovarian carcinoma. Mol Cell Endocrinol. 187:39–45. 2002.PubMed/NCBI | |
Kenny HA and Lengyel E: MMP-2 functions as an early response protein in ovarian cancer metastasis. Cell Cycle. 8:683–688. 2009.PubMed/NCBI | |
Symowicz J, Adley BP, Gleason KJ, Johnson JJ, Ghosh S, Fishman DA, Hudson LG and Stack MS: Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Cancer Res. 67:2030–2039. 2007.PubMed/NCBI | |
Kim JY, Yi BR, Go RE, Hwang KA, Nam KH and Choi KC: Methoxychlor and triclosan stimulates ovarian cancer growth by regulating cell cycle- and apoptosis-related genes via an estrogen receptor-dependent pathway. Environ Toxicol Pharmacol. 37:1264–1274. 2014.PubMed/NCBI | |
Teilmann G, Juul A, Skakkebaek NE and Toppari J: Putative effects of endocrine disrupters on pubertal development in the human. Best Pract Res Clin Endocrinol Metab. 16:105–121. 2002.PubMed/NCBI | |
Fenichel P, Chevalier N and Brucker-Davis F: Bisphenol A: An endocrine and metabolic disruptor. Ann Endocrinol (Paris). 74:211–220. 2013.PubMed/NCBI | |
Chibelean CB, Petca RC, Radu DC and Petca A: State of the art in fertility preservation for female patients prior to oncologic therapies. Medicina (Kaunas). 56:892020. | |
Tsuda H, Naito A, Kim CK, Fukamachi K, Nomoto H and Moore MA: Carcinogenesis and its modification by environmental endocrine disruptors: In vivo experimental and epidemiological findings. Jpn J Clin Oncol. 33:259–270. 2003.PubMed/NCBI | |
Fenton SE: Endocrine-disrupting compounds and mammary gland development: Early exposure and later life consequences. Endocrinology. 147 (Suppl):S18–S24. 2006.PubMed/NCBI | |
Fernandez SV and Russo J: Estrogen and xenoestrogens in breast cancer. Toxicol Pathol. 38:110–122. 2010.PubMed/NCBI | |
Wetherill YB, Akingbemi BT, Kanno J, McLachlan JA, Nadal A, Sonnenschein C, Watson CS, Zoeller RT and Belcher SM: In vitro molecular mechanisms of bisphenol A action. Reprod Toxicol. 24:178–198. 2007.PubMed/NCBI | |
Tharp AP, Maffini MV, Hunt PA, VandeVoort CA, Sonnenschein C and Soto AM: Bisphenol A alters the development of the rhesus monkey mammary gland. Proc Natl Acad Sci USA. 109:8190–8195. 2012.PubMed/NCBI | |
Murray TJ, Maffini MV, Ucci AA, Sonnenschein C and Soto AM: Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure. Reprod Toxicol. 23:383–390. 2007.PubMed/NCBI | |
Acevedo N, Davis B, Schaeberle CM, Sonnenschein C and Soto AM: Perinatally administered bisphenol a as a potential mammary gland carcinogen in rats. Environ Health Perspect. 121:1040–1046. 2013.PubMed/NCBI | |
Hofseth LJ, Raafat AM, Osuch JR, Pathak DR, Slomski CA and Haslam SZ: Hormone replacement therapy with estrogen or estrogen plus medroxyprogesterone acetate is associated with increased epithelial proliferation in the normal postmenopausal breast. J Clin Endocrinol Metab. 84:4559–4565. 1999.PubMed/NCBI | |
Santen RJ and Harvey HA: Use of aromatase inhibitors in breast carcinoma. Endocr Relat Cancer. 6:75–92. 1999.PubMed/NCBI | |
Zgura A, Gales L, Haineala B, Bratila E, Mehedintu C, Andreescu CV, Berceanu C, Petca A, Barac RI, Ionescu A, et al: Correlations between known prognostic markers and tumor - infiltrating lymphocytes in breast cancer. Rev Chim. 70:2362–2366. 2019. | |
Migliaccio A, Castoria G and Auricchio F: Src-dependent signalling pathway regulation by sex-steroid hormones: Therapeutic implications. Int J Biochem Cell Biol. 39:1343–1348. 2007.PubMed/NCBI | |
Castoria G, Migliaccio A, Di Domenico M, Lombardi M, de Falco A, Varricchio L, Bilancio A, Barone MV and Auricchio F: Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells. Mol Cell Biol. 24:7643–7653. 2004.PubMed/NCBI | |
Foulkes WD: Inherited susceptibility to common cancers. N Engl J Med. 359:2143–2153. 2008.PubMed/NCBI | |
Fernandez SV, Huang Y, Snider KE, Zhou Y, Pogash TJ and Russo J: Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 41:369–377. 2012.PubMed/NCBI | |
Jung JW, Park SB, Lee SJ, Seo MS, Trosko JE and Kang KS: Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression. PLoS One. 6:e280682011.PubMed/NCBI | |
Rathore A, Ranjan S and Dubey AP: Hereditary breast-ovarian cancer syndrome. Cancer Res Stat Treat. 3:374–375. 2020. | |
Lapensee EW, Tuttle TR, Fox SR and Ben-Jonathan N: Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-alpha-positive and -negative breast cancer cells. Environ Health Perspect. 117:175–180. 2009.PubMed/NCBI | |
Dairkee SH, Luciani-Torres MG, Moore DH and Goodson WH III: Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells. Carcinogenesis. 34:703–712. 2013.PubMed/NCBI | |
Zhang W, Fang Y, Shi X, Zhang M, Wang X and Tan Y: Effect of bisphenol A on the EGFR-STAT3 pathway in MCF-7 breast cancer cells. Mol Med Rep. 5:41–47. 2012.PubMed/NCBI | |
Buteau-Lozano H, Velasco G, Cristofari M, Balaguer P and Perrot-Applanat M: Xenoestrogens modulate vascular endothelial growth factor secretion in breast cancer cells through an estrogen receptor-dependent mechanism. J Endocrinol. 196:399–412. 2008.PubMed/NCBI | |
Dong S, Terasaka S and Kiyama R: Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells. Environ Pollut. 159:212–218. 2011.PubMed/NCBI | |
Radice S, Chiesara E, Fucile S and Marabini L: Different effects of PCB101, PCB118, PCB138 and PCB153 alone or mixed in MCF-7 breast cancer cells. Food Chem Toxicol. 46:2561–2567. 2008.PubMed/NCBI | |
Parada H Jr, Wolff MS, Engel LS, Eng SM, Khankari NK, Neugut AI, Teitelbaum SL and Gammon MD: Polychlorinated biphenyls and their association with survival following breast cancer. Eur J Cancer. 56:21–30. 2016.PubMed/NCBI | |
Combarnous Y and Nguyen TMD: Comparative overview of the mechanisms of action of hormones and endocrine disruptor compounds. Toxics. 7:52019. | |
Nagel SC and Bromfield JJ: Bisphenol a: A model endocrine disrupting chemical with a new potential mechanism of action. Endocrinology. 154:1962–1964. 2013.PubMed/NCBI | |
Li L, Wang Q, Zhang Y, Niu Y, Yao X and Liu H: The molecular mechanism of bisphenol A (BPA) as an endocrine disruptor by interacting with nuclear receptors: Insights from molecular dynamics (MD) simulations. PLoS One. 10:e01203302015.PubMed/NCBI | |
Acconcia F, Pallottini V and Marino M: Molecular mechanisms of action of BPA. Dose Response. 13:15593258156105822015.PubMed/NCBI | |
Paterni I, Granchi C and Minutolo F: Risks and benefits related to alimentary exposure to xenoestrogens. Crit Rev Food Sci Nutr. 57:3384–3404. 2017.PubMed/NCBI | |
Caserta D, Di Segni N, Mallozzi M, Giovanale V, Mantovani A, Marci R and Moscarini M: Bisphenol A and the female reproductive tract: An overview of recent laboratory evidence and epidemiological studies. Reprod Biol Endocrinol. 12:372014.PubMed/NCBI | |
Hui L, Li H, Lu G, Chen Z, Sun W, Shi Y, Fu Z, Huang B, Zhu X, Lu W, et al: Low dose of bisphenol a modulates ovarian cancer gene expression profile and promotes epithelial to mesenchymal transition via canonical wnt pathway. Toxicol Sci. 164:527–538. 2018.PubMed/NCBI | |
Weber Lozada K and Keri RA: Bisphenol A increases mammary cancer risk in two distinct mouse models of breast cancer. Biol Reprod. 85:490–497. 2011.PubMed/NCBI | |
Seachrist DD, Bonk KW, Ho SM, Prins GS, Soto AM and Keri RA: A review of the carcinogenic potential of bisphenol A. Reprod Toxicol. 59:167–182. 2016.PubMed/NCBI | |
Caporossi L and Papaleo B: Exposure to Bisphenol A and gender differences: From rodents to humans evidences and hypothesis about the health effects. J Xenobiot. 5:52642015.PubMed/NCBI |