Emerging role of ONECUT2 in tumors (Review)

  • Authors:
    • Jia Yu
    • Dongyang Li
    • Hua Jiang
  • View Affiliations

  • Published online on: October 6, 2020     https://doi.org/10.3892/ol.2020.12192
  • Article Number: 328
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Abstract

One cut domain family member 2 (ONECUT2), also termed OC‑2, is a newly discovered member of the ONECUT transcription factor family. As a transcription factor, ONECUT2 can widely regulate protein expression associated with cell proliferation, migration, adhesion, differentiation and cell material metabolism. Recent studies have revealed that ONECUT2 is associated with tumor cell proliferation, angiogenesis and metastasis; it is also associated with epithelial‑mesenchymal transition in cancer cells. The present review examines the distribution and expression of ONECUT2 in a variety of tumors, its oncogenic role in tumor progression and the possible mechanisms of regulation. Given the emerging role of ONECUT2 in the development and progression of tumors, ONECUT2 might be a promising target for tumor therapy.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yu J, Li D and Jiang H: Emerging role of ONECUT2 in tumors (Review). Oncol Lett 20: 328, 2020.
APA
Yu, J., Li, D., & Jiang, H. (2020). Emerging role of ONECUT2 in tumors (Review). Oncology Letters, 20, 328. https://doi.org/10.3892/ol.2020.12192
MLA
Yu, J., Li, D., Jiang, H."Emerging role of ONECUT2 in tumors (Review)". Oncology Letters 20.6 (2020): 328.
Chicago
Yu, J., Li, D., Jiang, H."Emerging role of ONECUT2 in tumors (Review)". Oncology Letters 20, no. 6 (2020): 328. https://doi.org/10.3892/ol.2020.12192