Open Access

Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review)

  • Authors:
    • Jian Wang
    • Hong-Ru Yang
    • Dai-Jie Wang
    • Xing-Xia Wang
  • View Affiliations

  • Published online on: October 8, 2020     https://doi.org/10.3892/ol.2020.12205
  • Article Number: 342
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Studies are increasingly investigating the association between the gut microbiota and the outcomes of immunotherapy in patients with cancer. Notably, certain studies have demonstrated that the gut microbiota serves a key role in regulating a patient's response to immunotherapy. In the present review, the potential associations between the gut microbiota, and cancer, host immunity and cancer immunotherapy are reviewed. Furthermore, the effects of fecal microbiota transplantation, antibiotics, probiotics, prebiotics, synbiotics, components of traditional Chinese medicine and various lifestyle factors on the gut microbiota and cancer immunotherapy outcomes are discussed. Certain dominant bacterial groups in the context of cancer immunotherapy and certain effective methods for optimizing immunotherapy by regulating the gut microbiota have been identified. Further investigation may enable the rapid conversion of these discoveries into practical products and clinically applicable methods.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang J, Yang H, Wang D and Wang X: Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review). Oncol Lett 20: 342, 2020
APA
Wang, J., Yang, H., Wang, D., & Wang, X. (2020). Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review). Oncology Letters, 20, 342. https://doi.org/10.3892/ol.2020.12205
MLA
Wang, J., Yang, H., Wang, D., Wang, X."Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review)". Oncology Letters 20.6 (2020): 342.
Chicago
Wang, J., Yang, H., Wang, D., Wang, X."Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review)". Oncology Letters 20, no. 6 (2020): 342. https://doi.org/10.3892/ol.2020.12205