Open Access

Roles of ten‑eleven translocation family proteins and their O‑linked β‑N‑acetylglucosaminylated forms in cancer development (Review)

  • Authors:
    • Hong-Jiao Li
    • Yi Wang
    • Bing-Xin Li
    • Yang Yang
    • Feng  Guan
    • Xing-Chen Pang
    • Xiang Li
  • View Affiliations

  • Published online on: November 3, 2020     https://doi.org/10.3892/ol.2020.12262
  • Article Number: 1
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Members of the ten‑eleven translocation (TET) protein family of which three mammalian TET proteins have been discovered so far, catalyze the sequential oxidation of 5‑methylcytosine to 5‑hydroxymethylcytosine, 5‑formylcytosine, and 5‑carboxylcytosine which serve an important role in embryonic development and tumor progression. O‑GlcNAcylation (O‑linked β‑N‑acetylglucosaminylation) is a reversible post‑translational modification known to serve important roles in tumorigenesis and metastasis especially in hematopoietic malignancies such as myelodysplastic syndromes, chronic myelomonocytic leukemia and acute myeloid leukemia. O‑GlcNAcylation activity requires only two enzymes: O‑GlcNAc transferase (OGT) and O‑GlcNAcase (OGA). OGT catalyzes attachment of GlcNAc sugar to serine, threonine and cytosine residues in proteins, while OGA hydrolyzes O‑GlcNAc attached to proteins. Numerous recent studies have demonstrated that TETs can be O‑GlcNAcylated by OGT, with consequent alteration of TET activity and stability. The present review focuses on the cellular, biological and biochemical functions of TET and its O‑GlcNAcylated form and proposes a model of the role of TET/OGT complex in regulation of target proteins during cancer development. In addition, the present review provides directions for future research in this area.
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January-2021
Volume 21 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Li H, Wang Y, Li B, Yang Y, Guan F, Pang X and Li X: Roles of ten‑eleven translocation family proteins and their O‑linked β‑N‑acetylglucosaminylated forms in cancer development (Review). Oncol Lett 21: 1, 2021.
APA
Li, H., Wang, Y., Li, B., Yang, Y., Guan, F., Pang, X., & Li, X. (2021). Roles of ten‑eleven translocation family proteins and their O‑linked β‑N‑acetylglucosaminylated forms in cancer development (Review). Oncology Letters, 21, 1. https://doi.org/10.3892/ol.2020.12262
MLA
Li, H., Wang, Y., Li, B., Yang, Y., Guan, F., Pang, X., Li, X."Roles of ten‑eleven translocation family proteins and their O‑linked β‑N‑acetylglucosaminylated forms in cancer development (Review)". Oncology Letters 21.1 (2021): 1.
Chicago
Li, H., Wang, Y., Li, B., Yang, Y., Guan, F., Pang, X., Li, X."Roles of ten‑eleven translocation family proteins and their O‑linked β‑N‑acetylglucosaminylated forms in cancer development (Review)". Oncology Letters 21, no. 1 (2021): 1. https://doi.org/10.3892/ol.2020.12262