Open Access

Regulation of microRNA‑497 expression in human cancer (Review)

  • Authors:
    • Guanshui Luo
    • Ke He
    • Zhenglin Xia
    • Shuai Liu
    • Hong Liu
    • Guoan Xiang
  • View Affiliations

  • Published online on: November 11, 2020     https://doi.org/10.3892/ol.2020.12284
  • Article Number: 23
  • Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRNAs/miRs) are a type of non‑coding single‑stranded RNA, with a length of ~22 nt, which are encoded by endogenous genes and are involved in the post‑transcriptional regulation of gene expression in animals and plants. Studies have demonstrated that miRNAs play an important role in the occurrence, development, metastasis, diagnosis and treatment of cancer. In recent years, miR‑497 has been identified as one of the key miRNAs in a variety of cancer types and has been shown to be downregulated in a variety of solid tumors. However, the regulation of miR‑497 expression involves a complex network, which is affected by several factors. The aim of the present review was to summarize the mechanism of regulation of miR‑497 expression at the pre‑transcriptional and transcriptional levels in cancer, as well as the role of miR‑497 expression imbalance in cancer diagnosis, treatment and prognosis. The regulatory mechanisms of miR‑497 expression may aid in our understanding of the causes of miR‑497 expression imbalance and provide a reference value for further research on the diagnosis and treatment of cancer.
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January-2021
Volume 21 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Luo G, He K, Xia Z, Liu S, Liu H and Xiang G: Regulation of microRNA‑497 expression in human cancer (Review). Oncol Lett 21: 23, 2021.
APA
Luo, G., He, K., Xia, Z., Liu, S., Liu, H., & Xiang, G. (2021). Regulation of microRNA‑497 expression in human cancer (Review). Oncology Letters, 21, 23. https://doi.org/10.3892/ol.2020.12284
MLA
Luo, G., He, K., Xia, Z., Liu, S., Liu, H., Xiang, G."Regulation of microRNA‑497 expression in human cancer (Review)". Oncology Letters 21.1 (2021): 23.
Chicago
Luo, G., He, K., Xia, Z., Liu, S., Liu, H., Xiang, G."Regulation of microRNA‑497 expression in human cancer (Review)". Oncology Letters 21, no. 1 (2021): 23. https://doi.org/10.3892/ol.2020.12284