Open Access

Cell‑based immunotherapy of glioblastoma multiforme (Review)

  • Authors:
    • Igor Bryukhovetskiy
  • View Affiliations

  • Published online on: February 23, 2022     https://doi.org/10.3892/ol.2022.13253
  • Article Number: 133
  • Copyright: © Bryukhovetskiy . This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioblastoma multiforme (GBM) is the most aggressive and lethal primary glial brain tumor. It has an unfavorable prognosis and relatively ineffective treatment protocols, with the median survival of patients being ~15 months. Tumor resistance to treatment is associated with its cancer stem cells (CSCs). At present, there is no medication or technologies that have the ability to completely eradicate CSCs, and immunotherapy (IT) is only able to prolong the patient's life. The present review aimed to investigate systemic solutions for issues associated with immunosuppression, such as ineffective IT and the creation of optimal conditions for CSCs to fulfill their lethal potential. The present review also investigated the main methods involved in local immunosuppression treatment, and highlighted the associated disadvantages. In addition, novel treatment options and targets for the elimination and regulation of CSCs with adaptive and active IT are discussed. Antagonists of TGF‑β inhibitors, immune checkpoints and other targeted medication are also summarized. The role of normal hematopoietic stem cells (HSCs) in the mechanisms underlying systemic immune suppression development in cases of GBM is analyzed, and the potential reprogramming of HSCs during their interaction with cancer cells is discussed. Moreover, the present review emphasizes the importance of the aforementioned interactions in the development of immune tolerance and the inactivation of the immune system in neoplastic processes. The possibility of solving the problem of systemic immunosuppression during transplantation of donor HSCs is discussed.
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April-2022
Volume 23 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Bryukhovetskiy I: Cell‑based immunotherapy of glioblastoma multiforme (Review). Oncol Lett 23: 133, 2022.
APA
Bryukhovetskiy, I. (2022). Cell‑based immunotherapy of glioblastoma multiforme (Review). Oncology Letters, 23, 133. https://doi.org/10.3892/ol.2022.13253
MLA
Bryukhovetskiy, I."Cell‑based immunotherapy of glioblastoma multiforme (Review)". Oncology Letters 23.4 (2022): 133.
Chicago
Bryukhovetskiy, I."Cell‑based immunotherapy of glioblastoma multiforme (Review)". Oncology Letters 23, no. 4 (2022): 133. https://doi.org/10.3892/ol.2022.13253