Open Access

Regulation of ROCK1/2 by long non‑coding RNAs and circular RNAs in different cancer types (Review)

  • Authors:
    • Ammad Ahmad Farooqi
    • Rabbia Zahid
    • Humaira Naureen
    • Rukset Attar
    • Maria Gazouli
    • Rossana Berardi
    • Jolanta Szelachowska
    • Rafał Matkowski
    • Edyta Pawlak
  • View Affiliations

  • Published online on: March 22, 2022     https://doi.org/10.3892/ol.2022.13279
  • Article Number: 159
  • Copyright: © Farooqi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Recent breakthroughs in high‑throughput technologies have enabled the development of a better understanding of the functionalities of rho‑associated protein kinases (ROCKs) under various physiological and pathological conditions. Since their discovery in the late 1990s, ROCKs have attracted the attention of interdisciplinary researchers due to their ability to pleiotropically modulate a myriad of cellular mechanisms. A rapidly growing number of published studies have started to shed light on the mechanisms underlying the regulation of ROCK1 and ROCK2 via long non‑coding RNAs (lncRNAs) and circular RNAs (circRNAs) in different types of cancer. Detailed analyses have suggested that lncRNAs may be characteristically divided into oncogenic and tumor suppressor lncRNAs. Several exciting recent discoveries have also indicated how different lncRNAs and circRNAs modulate ROCK1/2 and mediate multistep cancer onset and progression. The present review chronicles the major advances that have been made in our understanding of the regulatory role of ROCK1/2 in different types of cancer, and how wide‑ranging lncRNAs and circRNAs potentiate ROCK‑driven signaling by blocking the targeting activities of tumor suppressor microRNAs.
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May-2022
Volume 23 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Farooqi AA, Zahid R, Naureen H, Attar R, Gazouli M, Berardi R, Szelachowska J, Matkowski R and Pawlak E: Regulation of ROCK1/2 by long non‑coding RNAs and circular RNAs in different cancer types (Review). Oncol Lett 23: 159, 2022.
APA
Farooqi, A.A., Zahid, R., Naureen, H., Attar, R., Gazouli, M., Berardi, R. ... Pawlak, E. (2022). Regulation of ROCK1/2 by long non‑coding RNAs and circular RNAs in different cancer types (Review). Oncology Letters, 23, 159. https://doi.org/10.3892/ol.2022.13279
MLA
Farooqi, A. A., Zahid, R., Naureen, H., Attar, R., Gazouli, M., Berardi, R., Szelachowska, J., Matkowski, R., Pawlak, E."Regulation of ROCK1/2 by long non‑coding RNAs and circular RNAs in different cancer types (Review)". Oncology Letters 23.5 (2022): 159.
Chicago
Farooqi, A. A., Zahid, R., Naureen, H., Attar, R., Gazouli, M., Berardi, R., Szelachowska, J., Matkowski, R., Pawlak, E."Regulation of ROCK1/2 by long non‑coding RNAs and circular RNAs in different cancer types (Review)". Oncology Letters 23, no. 5 (2022): 159. https://doi.org/10.3892/ol.2022.13279