Open Access

Progress in neoadjuvant therapy for gastric cancer (Review)

  • Authors:
    • Peng-Fei Su
    • Jian-Chun Yu
  • View Affiliations

  • Published online on: April 13, 2022     https://doi.org/10.3892/ol.2022.13292
  • Article Number: 172
  • Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer is one of the most common malignant tumor types in the world and the majority of patients have already reached the advanced stage at the time of initial diagnosis, owing to the subtle symptoms of gastric cancer in the early stage and the low rate of screening in the population. Surgical resection is one of the main treatments for advanced gastric cancer; however, the efficacy of surgery is limited by factors such as low radical resection rate and high distant metastasis rate. A large number of clinical trials have indicated that neoadjuvant therapy (NAT), which consists of neoadjuvant chemotherapy, neoadjuvant chemoradiotherapy and NAT combined with targeted therapy, may improve the therapeutic effect and prognosis of patients to different degrees. However, the benefit of NAT remains controversial due to the heterogeneity of clinical trials and gastric cancer itself. The present review summarizes the main research progress and key breakthrough of NAT for advanced gastric cancer and discusses its prospects.
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June-2022
Volume 23 Issue 6

Print ISSN: 1792-1074
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Copy and paste a formatted citation
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Spandidos Publications style
Su P and Yu J: Progress in neoadjuvant therapy for gastric cancer (Review). Oncol Lett 23: 172, 2022.
APA
Su, P., & Yu, J. (2022). Progress in neoadjuvant therapy for gastric cancer (Review). Oncology Letters, 23, 172. https://doi.org/10.3892/ol.2022.13292
MLA
Su, P., Yu, J."Progress in neoadjuvant therapy for gastric cancer (Review)". Oncology Letters 23.6 (2022): 172.
Chicago
Su, P., Yu, J."Progress in neoadjuvant therapy for gastric cancer (Review)". Oncology Letters 23, no. 6 (2022): 172. https://doi.org/10.3892/ol.2022.13292