Open Access

Tumor metabolic reprogramming in lung cancer progression (Review)

  • Authors:
    • Xin Li
    • Minghui Liu
    • Hongyu Liu
    • Jun Chen
  • View Affiliations

  • Published online on: June 28, 2022     https://doi.org/10.3892/ol.2022.13407
  • Article Number: 287
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Metabolic reprogramming is an important characteristic of tumor cells. Tumor cells reprogram their metabolic pathways to meet the material, energy and redox force needs for rapid proliferation. Metabolic reprogramming changes the level or type of specific metabolites inside and outside cells, and promotes tumor growth by affecting gene expression, cell state and the tumor microenvironment. Glucose metabolism, glutamine metabolism and lipid metabolism are significant metabolic pathways in tumors. Targeting metabolic reprogramming can significantly inhibit tumor growth and induce apoptosis. Metabolic reprogramming also plays an important role in maintaining the growth advantage of tumor cells and enhancing the chemotherapy tolerance of lung cancer. This review summarizes abnormal changes in the metabolism of glucose, fat and amino acids in lung cancer, and the underlying molecular mechanism, with the aim of providing novel ideas for the prevention, early diagnosis and treatment of lung cancer.
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August-2022
Volume 24 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Li X, Liu M, Liu H and Chen J: Tumor metabolic reprogramming in lung cancer progression (Review). Oncol Lett 24: 287, 2022.
APA
Li, X., Liu, M., Liu, H., & Chen, J. (2022). Tumor metabolic reprogramming in lung cancer progression (Review). Oncology Letters, 24, 287. https://doi.org/10.3892/ol.2022.13407
MLA
Li, X., Liu, M., Liu, H., Chen, J."Tumor metabolic reprogramming in lung cancer progression (Review)". Oncology Letters 24.2 (2022): 287.
Chicago
Li, X., Liu, M., Liu, H., Chen, J."Tumor metabolic reprogramming in lung cancer progression (Review)". Oncology Letters 24, no. 2 (2022): 287. https://doi.org/10.3892/ol.2022.13407