Open Access

Role of circular RNAs in the diagnosis, regulation of drug resistance and prognosis of lung cancer (Review)

  • Authors:
    • Chengpeng Sang
    • Dingyu Rao
    • Caixia Wu
    • Yao Xia
    • Maoyan Si
    • Zhixian Tang
  • View Affiliations

  • Published online on: July 7, 2022     https://doi.org/10.3892/ol.2022.13422
  • Article Number: 302
  • Copyright: © Sang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung cancer is one of the most common malignant tumors in China and is the highest cause of mortality among male and female patients, both in urban and rural areas. A subset of patients with lung cancer only display chest tightness without any other obvious symptoms. This is because most symptoms do not manifest during the early stages of disease development. Consequently, most patients with lung cancer are diagnosed when the disease is in the advanced stages, when they are already unfit for surgical treatment. Furthermore, the prognosis of patients with lung cancer is poor. The 5‑year survival rate of patients with stage IA lung cancer is 85%, compared with 6% in those with stage IV. This requires the development of strategies for early diagnosis, treatment and prognosis to improve the management of lung cancer. Circular RNAs (circRNAs) belong to a class of closed circular non‑coding RNAs formed by reverse splicing of a precursor mRNA. These RNAs are highly stable, ubiquitously expressed, conserved, and show high specificity. CircRNAs regulate biological processes, such as the proliferation, differentiation and invasion of lung cancer cells. Therefore, they can be used as biomarkers for the early diagnosis and prognosis prediction of lung cancer, as well as novel targets for therapy design. In the present review, the biological characteristics and functions of circRNAs, as well as their application in the diagnosis, control of drug resistance and effect on the prognosis of patients with lung cancer, will be discussed.
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September-2022
Volume 24 Issue 3

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Copy and paste a formatted citation
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Spandidos Publications style
Sang C, Rao D, Wu C, Xia Y, Si M and Tang Z: Role of circular RNAs in the diagnosis, regulation of drug resistance and prognosis of lung cancer (Review). Oncol Lett 24: 302, 2022.
APA
Sang, C., Rao, D., Wu, C., Xia, Y., Si, M., & Tang, Z. (2022). Role of circular RNAs in the diagnosis, regulation of drug resistance and prognosis of lung cancer (Review). Oncology Letters, 24, 302. https://doi.org/10.3892/ol.2022.13422
MLA
Sang, C., Rao, D., Wu, C., Xia, Y., Si, M., Tang, Z."Role of circular RNAs in the diagnosis, regulation of drug resistance and prognosis of lung cancer (Review)". Oncology Letters 24.3 (2022): 302.
Chicago
Sang, C., Rao, D., Wu, C., Xia, Y., Si, M., Tang, Z."Role of circular RNAs in the diagnosis, regulation of drug resistance and prognosis of lung cancer (Review)". Oncology Letters 24, no. 3 (2022): 302. https://doi.org/10.3892/ol.2022.13422