Open Access

Insight into the physiological and pathological roles of USP44, a potential tumor target (Review)

  • Authors:
    • Yuming Lou
    • Minfeng Ye
    • Chaoyang Xu
    • Feng Tao
  • View Affiliations

  • Published online on: November 1, 2022     https://doi.org/10.3892/ol.2022.13575
  • Article Number: 455
  • Copyright: © Lou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ubiquitin‑specific peptidase 44 (USP44) is a member of the ubiquitin‑specific proteases (USPs) family and its functions in various biological processes have been gradually elucidated in recent years. USP44 targets multiple downstream factors and regulates multiple mechanisms through its deubiquitination activity. Ubiquitination is, in essence, a process in which a single ubiquitin molecule or a multiubiquitin chain binds to a substrate protein to form an isopeptide bond. Deubiquitination is the catalyzing of the isopeptide bonds between ubiquitin and substrate proteins through deubiquitylating enzymes. These two processes serve an important role in the regulation of the expression, conformation, localization and function of substrate proteins by regulating their binding to ubiquitin. Based on existing research, this paper summarized the current state of knowledge about USP44. The physiological roles of USP44 in various cellular events and its pathophysiological roles in different cancer types are evaluated and the therapeutic potential of USP44 for cancer treatment is evaluated.
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December-2022
Volume 24 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Lou Y, Ye M, Xu C and Tao F: Insight into the physiological and pathological roles of USP44, a potential tumor target (Review). Oncol Lett 24: 455, 2022.
APA
Lou, Y., Ye, M., Xu, C., & Tao, F. (2022). Insight into the physiological and pathological roles of USP44, a potential tumor target (Review). Oncology Letters, 24, 455. https://doi.org/10.3892/ol.2022.13575
MLA
Lou, Y., Ye, M., Xu, C., Tao, F."Insight into the physiological and pathological roles of USP44, a potential tumor target (Review)". Oncology Letters 24.6 (2022): 455.
Chicago
Lou, Y., Ye, M., Xu, C., Tao, F."Insight into the physiological and pathological roles of USP44, a potential tumor target (Review)". Oncology Letters 24, no. 6 (2022): 455. https://doi.org/10.3892/ol.2022.13575