Open Access

Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer

  • Authors:
    • Santiago Cabezas-Camarero
    • Salomé Merino-Menéndez
    • María Nieves Cabrera-Martín
    • Miguel J. Sotelo
    • José Carlos Plaza-Hernández
    • Farzin Falahat
    • María Cruz Iglesias-Moreno
    • Pedro Pérez-Segura
  • View Affiliations

  • Published online on: December 7, 2022     https://doi.org/10.3892/ol.2022.13623
  • Article Number: 37
  • Copyright: © Cabezas-Camarero et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Novel chemo‑immunotherapy (chemo‑IO) combinations should be evaluated, which may be suitable for cisplatin‑unfit or fluoropyrimide‑ineligible patients with recurrent or metastatic squamous cell carcinoma of head and neck (R/M SCCHN) to guarantee higher and deeper responses than IO alone. The aim of the present study was to review our experience using pembrolizumab‑carboplatin‑paclitaxel (pembro + CP) in patients with R/M SCCHN. This was a retrospective study of patients with R/M SCCHN who received pembro + CP in any‑line via a compassionate‑use program. The present study evaluated safety using Common Terminology Criteria for Adverse Events v4.0, compliance, overall response rate (ORR) and disease control rate (DCR) using Response Evaluation Criteria in Solid Tumors 1.1, duration of treatment, progression‑free survival (PFS) and overall survival (OS). Between March 2020 and August 2021, 10 patients were identified (median age, 64 years; female, 60%; Eastern Cooperative Oncology Group 2, 80%). A total of 8 patients received pembro + 3‑weekly carboplatin‑paclitaxel (3wkCP). A total of 2 patients received pembro + weekly carboplatin‑paclitaxel (wkCP). Patients received a median of 3 lines (range, 0‑6) of systemic therapy prior to pembro + CP and 80% received IO in previous lines. Grade 1‑2 adverse events (AEs) occurred in 100% of patients. Grade 3‑5 AEs occurred in 30% of patients [all grade 3 (anemia, neutropenia, thrombopenia, hypertension)]. The mean numbers of pembro + wkCP and pembro + 3wkCP cycles were 2.5 and 6. The ORR (n=7) was 14% (1/7) with one complete response. The DCR was 43% (3/7). The median PFS (n=7) and OS (n=10) times since pembro + CP were 5 months (95% CI, 1‑9) and 6 months (95% CI, 0.5‑14), respectively. In this small retrospective series of heavily pretreated patients, pembro + CP was well tolerated, and compliance was high. Studies should be conducted to prospectively evaluate the safety and efficacy of this combination in patients with R/M SCCHN.
View Figures
View References

Related Articles

Journal Cover

January-2023
Volume 25 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cabezas-Camarero S, Merino-Menéndez S, Cabrera-Martín MN, Sotelo MJ, Plaza-Hernández JC, Falahat F, Iglesias-Moreno MC and Pérez-Segura P: Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer. Oncol Lett 25: 37, 2023
APA
Cabezas-Camarero, S., Merino-Menéndez, S., Cabrera-Martín, M.N., Sotelo, M.J., Plaza-Hernández, J.C., Falahat, F. ... Pérez-Segura, P. (2023). Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer. Oncology Letters, 25, 37. https://doi.org/10.3892/ol.2022.13623
MLA
Cabezas-Camarero, S., Merino-Menéndez, S., Cabrera-Martín, M. N., Sotelo, M. J., Plaza-Hernández, J. C., Falahat, F., Iglesias-Moreno, M. C., Pérez-Segura, P."Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer". Oncology Letters 25.1 (2023): 37.
Chicago
Cabezas-Camarero, S., Merino-Menéndez, S., Cabrera-Martín, M. N., Sotelo, M. J., Plaza-Hernández, J. C., Falahat, F., Iglesias-Moreno, M. C., Pérez-Segura, P."Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer". Oncology Letters 25, no. 1 (2023): 37. https://doi.org/10.3892/ol.2022.13623