Open Access

Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review)

  • Authors:
    • Yoshiko Tsuji
    • Tomoaki Hara
    • Sikun Meng
    • Hiromichi Sato
    • Yasuko Arao
    • Ken Ofusa
    • Hideshi Ishii
  • View Affiliations

  • Published online on: June 20, 2023     https://doi.org/10.3892/ol.2023.13922
  • Article Number: 336
  • Copyright: © Tsuji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic cancer stem cells (CSCs) play a key role in the initiation and progression of pancreatic adenocarcinoma (PDAC). CSCs are responsible for resistance to chemotherapy and radiation, and for cancer metastasis. Recent studies have indicated that RNA methylation, a type of RNA modification, predominantly occurring as m6A methylation, plays an important role in controlling the stemness of cancer cells, therapeutic resistance against chemotherapy and radiation therapy, and their overall relevance to a patient's prognosis. CSCs regulate various behaviors of cancer through cell‑cell communication by secreting factors, through their receptors, and through signal transduction. Recent studies have shown that RNA methylation is involved in the biology of the heterogeneity of PDAC. The present review provides an update on the current understanding of RNA modification‑based therapeutic targets against deleterious PDAC. Several key pathways and agents that can specifically target CSCs have been identified, thus providing novel insights into the early diagnosis and efficient treatment of PDAC.
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August-2023
Volume 26 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Tsuji Y, Hara T, Meng S, Sato H, Arao Y, Ofusa K and Ishii H: Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review). Oncol Lett 26: 336, 2023
APA
Tsuji, Y., Hara, T., Meng, S., Sato, H., Arao, Y., Ofusa, K., & Ishii, H. (2023). Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review). Oncology Letters, 26, 336. https://doi.org/10.3892/ol.2023.13922
MLA
Tsuji, Y., Hara, T., Meng, S., Sato, H., Arao, Y., Ofusa, K., Ishii, H."Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review)". Oncology Letters 26.2 (2023): 336.
Chicago
Tsuji, Y., Hara, T., Meng, S., Sato, H., Arao, Y., Ofusa, K., Ishii, H."Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review)". Oncology Letters 26, no. 2 (2023): 336. https://doi.org/10.3892/ol.2023.13922