Open Access

Serum cell division cycle 42 reflects the treatment response and survival in patients with advanced cervical cancer who receive immune checkpoint inhibitor treatment

  • Authors:
    • Lili Guo
    • Yue Su
    • Xiaoyu Liu
    • Wan Xie
    • Silu Meng
    • Yuhuan Liu
    • Weijiao Wang
    • Xiaofeng Lv
    • Changyu Wang
  • View Affiliations

  • Published online on: August 8, 2023     https://doi.org/10.3892/ol.2023.14000
  • Article Number: 414
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cell division cycle 42 (CDC42) regulates immune escape, which predicts immune checkpoint inhibitor (ICI) treatment response in several types of cancer. The present study aimed to evaluate the potential of serum CDC42 in predicting the ICI treatment outcome in patients with advanced cervical cancer. A total of 46 patients with advanced cervical cancer who received ICI treatment with or without antiangiogenic agents were enrolled. Serum CDC42 was detected in all patients before treatment (baseline) and following two treatment cycles by enzyme‑linked immunosorbent assay. CDC42 at baseline was elevated in patients with target lesion size ≥5 cm (P=0.020), pelvis metastasis (P=0.031) and lung metastasis (P=0.043). Following treatment, the objective response rate (ORR) and disease control rate (DCR) were 30.4 and 78.3%, respectively. Meanwhile, the median progression‑free survival (PFS) and overall survival (OS) were 5.8 and 13.1 months. CDC42 at baseline was decreased in patients achieving ORR (P=0.042) but not DCR (P=0.055). PFS (P=0.006) and OS (P=0.019) were decreased in patients with baseline CDC42 ≥600 pg/ml. After two treatment cycles, CDC42 was generally reduced (P<0.001). CDC42 following two treatment cycles was more significantly decreased in patients with ORR (P=0.032) and DCR (P=0.019). Multivariate Cox's regression analysis showed that CDC42 ≥600 pg/ml following two treatment cycles was associated with the shorter PFS (P=0.022, hazard ratio=2.469) and OS (P=0.013, hazard ratio=4.166). Serum CDC42 was reduced after treatment; high expression following treatment reflected a lower possibility of achieving treatment response and poorer survival in patients with advanced cervical cancer.
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September-2023
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Spandidos Publications style
Guo L, Su Y, Liu X, Xie W, Meng S, Liu Y, Wang W, Lv X and Wang C: Serum cell division cycle 42 reflects the treatment response and survival in patients with advanced cervical cancer who receive immune checkpoint inhibitor treatment. Oncol Lett 26: 414, 2023
APA
Guo, L., Su, Y., Liu, X., Xie, W., Meng, S., Liu, Y. ... Wang, C. (2023). Serum cell division cycle 42 reflects the treatment response and survival in patients with advanced cervical cancer who receive immune checkpoint inhibitor treatment. Oncology Letters, 26, 414. https://doi.org/10.3892/ol.2023.14000
MLA
Guo, L., Su, Y., Liu, X., Xie, W., Meng, S., Liu, Y., Wang, W., Lv, X., Wang, C."Serum cell division cycle 42 reflects the treatment response and survival in patients with advanced cervical cancer who receive immune checkpoint inhibitor treatment". Oncology Letters 26.3 (2023): 414.
Chicago
Guo, L., Su, Y., Liu, X., Xie, W., Meng, S., Liu, Y., Wang, W., Lv, X., Wang, C."Serum cell division cycle 42 reflects the treatment response and survival in patients with advanced cervical cancer who receive immune checkpoint inhibitor treatment". Oncology Letters 26, no. 3 (2023): 414. https://doi.org/10.3892/ol.2023.14000