Preoperative serum tissue factor pathway inhibitor‑2 level as a prognostic marker for endometrial cancer

  • Authors:
    • Ryuji Kawaguchi
    • Tomoka Maehana
    • Shoichiro Yamanaka
    • Ryuta Miyake
    • Naoki Kawahara
    • Kana Iwai
    • Yuki Yamada
    • Fuminori Kimura
  • View Affiliations

  • Published online on: September 13, 2023     https://doi.org/10.3892/ol.2023.14050
  • Article Number: 463
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Abstract

Advanced endometrial cancer (EC) often recurs and has a poor prognosis. Various serum markers have been used for EC but their usefulness as biomarkers is still unclear; therefore, identifying new biomarkers is important. The present study aimed to investigate whether the tissue factor pathway inhibitor‑2 (TFPI2) level was elevated in the preoperative serum of patients with EC and if it may be a prognostic factor. The present retrospective study included 207 patients who had a confirmed pathological diagnosis of EC and received surgical therapy as the initial treatment between January 2011 and December 2017. Survival analysis was performed using Kaplan‑Meier analysis and the Cox proportional hazards regression model. The 5‑year disease‑free survival and overall survival (OS) rates were 73.3 and 83.7%, respectively. The cut‑off value for predicting OS for TFPI2 level was 177 pg/ml as determined from the receiver operating characteristic curve. A TFPI2 value ≥177 pg/ml was significantly associated with age ≥65 years (P<0.001), diabetes (P=0.035), stage (P<0.001), myometrial invasion (P<0.001), lymphovascular invasion (P=0.004), lymph node metastasis (P=0.010), distant metastasis (P<0.001), cancer antigen (CA) 125 ≥36 U/ml (P<0.001) and CA 19‑9 ≥38 U/ml (P<0.001). In multivariate analysis, high‑grade carcinoma [hazard ratio (HR), 2.439; P=0.041], lymph node metastasis (HR, 2.116; P=0.038), distant metastasis (HR, 3.604; P=0.009) and TFPI2 level ≥177 pg/ml (HR, 2.42; P=0.043) were significant prognostic factors affecting OS in patients with EC. These results suggest that the preoperative serum TFPI2 level, along with its histological type, lymph node metastasis and distant metastasis, was a prognostic factor for OS in patients with endometrial cancer.
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November-2023
Volume 26 Issue 5

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Spandidos Publications style
Kawaguchi R, Maehana T, Yamanaka S, Miyake R, Kawahara N, Iwai K, Yamada Y and Kimura F: Preoperative serum tissue factor pathway inhibitor‑2 level as a prognostic marker for endometrial cancer. Oncol Lett 26: 463, 2023
APA
Kawaguchi, R., Maehana, T., Yamanaka, S., Miyake, R., Kawahara, N., Iwai, K. ... Kimura, F. (2023). Preoperative serum tissue factor pathway inhibitor‑2 level as a prognostic marker for endometrial cancer. Oncology Letters, 26, 463. https://doi.org/10.3892/ol.2023.14050
MLA
Kawaguchi, R., Maehana, T., Yamanaka, S., Miyake, R., Kawahara, N., Iwai, K., Yamada, Y., Kimura, F."Preoperative serum tissue factor pathway inhibitor‑2 level as a prognostic marker for endometrial cancer". Oncology Letters 26.5 (2023): 463.
Chicago
Kawaguchi, R., Maehana, T., Yamanaka, S., Miyake, R., Kawahara, N., Iwai, K., Yamada, Y., Kimura, F."Preoperative serum tissue factor pathway inhibitor‑2 level as a prognostic marker for endometrial cancer". Oncology Letters 26, no. 5 (2023): 463. https://doi.org/10.3892/ol.2023.14050