Open Access

Osteopontin regulates the growth and invasion of liver cancer cells via DTL

  • Authors:
    • Zhiyong Liu
    • Guang Yang
    • Xiaoyu Yi
    • Shijie Zhang
    • Zhibo Feng
    • Xudong Cui
    • Feilong Chen
    • Lei Yu
  • View Affiliations

  • Published online on: September 21, 2023     https://doi.org/10.3892/ol.2023.14064
  • Article Number: 476
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteopontin (OPN), a secreted phosphoglycoprotein, has important roles in tumor growth, invasion and metastasis in numerous types of cancers. Denticleless E3 ubiquitin protein ligase homolog (DTL), one of the CUL4‑DDB1‑associated factors (DCAFs), has also been associated with the invasion and metastasis of cancer cells. In the present study, OPN was found to induce DTL expression in liver cancer cells, and the results obtained using luciferase activity assays demonstrated that OPN could transcriptionally activate DTL expression in liver cancer cells. Furthermore, the results of the present study demonstrated that OPN could increase the expression of DTL via PI3K/AKT signaling. In conclusion, the present study demonstrated that OPN, as an extracellular matrix protein, is able to promote the growth and invasion of liver cancer cells through stimulation of the expression of DTL via the PI3K/AKT signaling pathway.
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November-2023
Volume 26 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liu Z, Yang G, Yi X, Zhang S, Feng Z, Cui X, Chen F and Yu L: Osteopontin regulates the growth and invasion of liver cancer cells via DTL. Oncol Lett 26: 476, 2023.
APA
Liu, Z., Yang, G., Yi, X., Zhang, S., Feng, Z., Cui, X. ... Yu, L. (2023). Osteopontin regulates the growth and invasion of liver cancer cells via DTL. Oncology Letters, 26, 476. https://doi.org/10.3892/ol.2023.14064
MLA
Liu, Z., Yang, G., Yi, X., Zhang, S., Feng, Z., Cui, X., Chen, F., Yu, L."Osteopontin regulates the growth and invasion of liver cancer cells via DTL". Oncology Letters 26.5 (2023): 476.
Chicago
Liu, Z., Yang, G., Yi, X., Zhang, S., Feng, Z., Cui, X., Chen, F., Yu, L."Osteopontin regulates the growth and invasion of liver cancer cells via DTL". Oncology Letters 26, no. 5 (2023): 476. https://doi.org/10.3892/ol.2023.14064