Sustained response to anlotinib in advanced pancreatic neuroendocrine carcinoma: A case report

  • Authors:
    • Yan Zhang
    • Yanchun Wang
    • Jingjing Wu
    • Zhihong Zhong
    • Jie Li
    • Xi Chen
  • View Affiliations

  • Published online on: February 2, 2024     https://doi.org/10.3892/ol.2024.14271
  • Article Number: 138
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Abstract

Pancreatic neuroendocrine carcinoma (pNEC) is a type of pancreatic neuroendocrine neoplasm with a poor prognosis, and patients with metastatic pNEC have a survival time of only 8‑12 months. The treatment options for pNEC are minimal, and the prognosis is unfavorable. The present study reports the case of a 56‑year‑old male who was diagnosed with advanced pNEC with bone metastases in June 2018. The patient was treated with oral anlotinib after eight cycles of first‑line etoposide + cisplatin (EP) chemotherapy until July 2022. The adverse events that occurred during the treatment period were resolved with symptomatic management or drug dose reduction. At the time of writing this report, the patient's survival time was almost 60 months, which is rare for patients with pNEC. This case report suggests that patients with pNEC treated with first‑line EP regimen chemotherapy may have a sustained response to anlotinib.
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April-2024
Volume 27 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang Y, Wang Y, Wu J, Zhong Z, Li J and Chen X: Sustained response to anlotinib in advanced pancreatic neuroendocrine carcinoma: A case report. Oncol Lett 27: 138, 2024.
APA
Zhang, Y., Wang, Y., Wu, J., Zhong, Z., Li, J., & Chen, X. (2024). Sustained response to anlotinib in advanced pancreatic neuroendocrine carcinoma: A case report. Oncology Letters, 27, 138. https://doi.org/10.3892/ol.2024.14271
MLA
Zhang, Y., Wang, Y., Wu, J., Zhong, Z., Li, J., Chen, X."Sustained response to anlotinib in advanced pancreatic neuroendocrine carcinoma: A case report". Oncology Letters 27.4 (2024): 138.
Chicago
Zhang, Y., Wang, Y., Wu, J., Zhong, Z., Li, J., Chen, X."Sustained response to anlotinib in advanced pancreatic neuroendocrine carcinoma: A case report". Oncology Letters 27, no. 4 (2024): 138. https://doi.org/10.3892/ol.2024.14271