Implication of PD‑L1 polymorphisms rs2297136 on clinical outcomes of patients with advanced NSCLC who received PD‑1 blockades: A retrospective exploratory study

  • Authors:
    • Qiang Gong
    • Hai-Ling Qie
    • Shao-Yong Dong
    • Hong-Tao Jiang
  • View Affiliations

  • Published online on: February 7, 2024     https://doi.org/10.3892/ol.2024.14277
  • Article Number: 144
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Clinically, programmed death‑1 (PD‑1) blockades have demonstrated promising therapeutic outcomes for patients with advanced non‑small cell lung cancer (NSCLC). The present study aimed to examine the impact of programmed death‑ligand 1 (PD‑L1) polymorphism on clinical outcomes of patients with advanced NSCLC who were treated with PD‑1 blockades therapy. The present study was designed as a retrospective analysis, where a consecutive screening of 89 patients with advanced NSCLC who received PD‑1 blockades monotherapy were screened. Biological specimens were collected to determine the presence of polymorphism and PD‑L1 mRNA expression through genotyping. The analysis focused on examining the relationship between the genotype status of PD‑L1 polymorphism and clinical outcomes. Among the 89 patients with advanced NSCLC, the use of PD‑1 blockades monotherapy resulted in objective response rate (ORR) of 22.5%, a median progression‑free survival (PFS) of 3.4 months [95% Confidence Interval (CI): 1.80‑5.00) and a median overall survival (OS) of 11.3 months (95% CI: 7.93‑14.67). The analysis of polymorphism indicated that only rs2297136 had clinical significance. Among the 89 patients with NSCLC, the prevalence of rs2297136 was as follows: A total of 58 cases (65.2%) had the AA genotype, 28 cases (31.5%) had the AG genotype and 3 cases (3.4%) had the GG genotype. This resulted in a minor allele frequency of 0.19, which was in consistent with Hardy‑Weinberg Equilibrium (P=0.865). The correlation analysis between genotype status of rs2297136 and clinical outcomes indicated that patients with the AA genotype had an ORR of 19.0%, while those with the AG/GG genotype had an ORR of 29.0% (P=0.278). Additionally, the median PFS for the AA genotype was 2.95 months, compared with 5.30 months for the AG/GG genotype (P=0.038). Accordingly, median OS of the AA and AG/GG genotypes was 8.8 and 18.4 months, respectively (P=0.011). The mRNA expression of PD‑L1 was significantly higher in patients with AG/GG genotype compared with those with AA genotype (P<0.001). In clinical practice, PD‑1 blockades demonstrated promising effectiveness in treating patients with advanced NSCLC. The presence of the rs2297136 variant in PD‑L1 gene could potentially be used as a biomarker to predict the clinical outcomes of PD‑1 blockades.
View Figures
View References

Related Articles

Journal Cover

April-2024
Volume 27 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gong Q, Qie H, Dong S and Jiang H: Implication of PD‑L1 polymorphisms rs2297136 on clinical outcomes of patients with advanced NSCLC who received PD‑1 blockades: A retrospective exploratory study. Oncol Lett 27: 144, 2024.
APA
Gong, Q., Qie, H., Dong, S., & Jiang, H. (2024). Implication of PD‑L1 polymorphisms rs2297136 on clinical outcomes of patients with advanced NSCLC who received PD‑1 blockades: A retrospective exploratory study. Oncology Letters, 27, 144. https://doi.org/10.3892/ol.2024.14277
MLA
Gong, Q., Qie, H., Dong, S., Jiang, H."Implication of PD‑L1 polymorphisms rs2297136 on clinical outcomes of patients with advanced NSCLC who received PD‑1 blockades: A retrospective exploratory study". Oncology Letters 27.4 (2024): 144.
Chicago
Gong, Q., Qie, H., Dong, S., Jiang, H."Implication of PD‑L1 polymorphisms rs2297136 on clinical outcomes of patients with advanced NSCLC who received PD‑1 blockades: A retrospective exploratory study". Oncology Letters 27, no. 4 (2024): 144. https://doi.org/10.3892/ol.2024.14277