Open Access

The numerous facets of 1q21+ in multiple myeloma: Pathogenesis, clinicopathological features, prognosis and clinical progress (Review)

  • Authors:
    • Na Liu
    • Zhanzhi Xie
    • Hao Li
    • Luqun Wang
  • View Affiliations

  • Published online on: April 9, 2024     https://doi.org/10.3892/ol.2024.14391
  • Article Number: 258
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Multiple myeloma (MM) is a malignant neoplasm characterized by the clonal proliferation of abnormal plasma cells (PCs) in the bone marrow and recurrent cytogenetic abnormalities. The incidence of MM worldwide is on the rise. 1q21+ has been found in ~30‑40% of newly diagnosed MM (NDMM) patients.1q21+ is associated with the pathophysiological mechanisms of disease progression and drug resistance in MM. In the present review, the pathogenesis and clinicopathological features of MM patients with 1q21+ were studied, the key data of 1q21+ on the prognosis of MM patients were summarized, and the clinical treatment significance of MM patients with 1q21+ was clarified, in order to provide reference for clinicians to develop treatment strategies targeting 1q21+.
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June-2024
Volume 27 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liu N, Xie Z, Li H and Wang L: The numerous facets of 1q21<sup>+</sup> in multiple myeloma: Pathogenesis, clinicopathological features, prognosis and clinical progress (Review). Oncol Lett 27: 258, 2024.
APA
Liu, N., Xie, Z., Li, H., & Wang, L. (2024). The numerous facets of 1q21<sup>+</sup> in multiple myeloma: Pathogenesis, clinicopathological features, prognosis and clinical progress (Review). Oncology Letters, 27, 258. https://doi.org/10.3892/ol.2024.14391
MLA
Liu, N., Xie, Z., Li, H., Wang, L."The numerous facets of 1q21<sup>+</sup> in multiple myeloma: Pathogenesis, clinicopathological features, prognosis and clinical progress (Review)". Oncology Letters 27.6 (2024): 258.
Chicago
Liu, N., Xie, Z., Li, H., Wang, L."The numerous facets of 1q21<sup>+</sup> in multiple myeloma: Pathogenesis, clinicopathological features, prognosis and clinical progress (Review)". Oncology Letters 27, no. 6 (2024): 258. https://doi.org/10.3892/ol.2024.14391