search button
Open Access

Molecular subtype and risk of local recurrence after nipple‑sparing mastectomy for breast cancer

  • Authors:
    • Danica Golijanin
    • Zoran Radovanović
    • Dragana Radovanović
    • Aleksandar Đermanović
    • Sanja Starčević
    • Marija Đermanović

  • View Affiliations

  • Published online on: June 21, 2024     https://doi.org/10.3892/ol.2024.14522
  • Article Number: 389

  • Copyright: © Golijanin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to investigate whether local recurrence (LR) after nipple‑sparing mastectomy (NSM) and reconstruction was associated with i) Ki67 values and molecular subtypes of the initial lesions, and ii) the size of the initial tumor and the size of the implant. A total of 156 patients with breast cancer with a mean age of 51.58 years (age range, 26‑75 years) who underwent NSM with primary implant breast reconstruction were analyzed. After surgery, the mean follow‑up time was 59.26 months (range, 17‑85 months). Molecular subtypes, Ki67 values, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status were recorded for each patient. Additionally, information regarding the size of the implant and the initial tumor size were collected. The information was used to assess LR. For univariate analyses of risk factors, χ2 test, Fisher's exact test, Mann‑Whitney U test and Student's t‑test for independent samples were used. For multivariate analyses, a Cox proportional‑hazards model was used. NSM was the primary treatment for breast cancer in 34/156 patients (21.8%), while 122/156 (78.2%) of patients received neoadjuvant chemotherapy followed by surgery. Luminal B was the most frequent molecular subtype, detected in 82/156 patients (52.6%), whereas the luminal A subtype was detected in 37 patients (23.7%) and the HER2‑enriched subtype was detected in 17/156 patients (10.9%). Ki67 expression was low in 13/156 patients (8.3%), while medium expression was detected in 78/156 patients (50.0%) and high expression was present in 58/156 patients (37.2%). LR was noted in 17/156 patients (10.9%). As determined by univariate analysis, lower ER (P=0.010) and PR (P=0.008) expression were indicated to be significant risk factors for LR. In conclusion, in the present patient cohort, low ER and PR expression were risk factors for LR of breast cancer, whereas Ki67 status and molecular subtype were not statistically significant risk factors for LR. Additionally, the size of the initial tumor and the size of the implant were not risk factors for LR. These findings are consistent with the current literature, and should be utilized when discussing treatment options and potential clinical outcomes with patients prior to surgical management.
View References

Related Articles

Journal Cover

August-2024
Volume 28 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Golijanin D, Radovanović Z, Radovanović D, Đermanović A, Starčević S and Đermanović M: Molecular subtype and risk of local recurrence after nipple‑sparing mastectomy for breast cancer. Oncol Lett 28: 389, 2024
APA
Golijanin, D., Radovanović, Z., Radovanović, D., Đermanović, A., Starčević, S., & Đermanović, M. (2024). Molecular subtype and risk of local recurrence after nipple‑sparing mastectomy for breast cancer. Oncology Letters, 28, 389. https://doi.org/10.3892/ol.2024.14522
MLA
Golijanin, D., Radovanović, Z., Radovanović, D., Đermanović, A., Starčević, S., Đermanović, M."Molecular subtype and risk of local recurrence after nipple‑sparing mastectomy for breast cancer". Oncology Letters 28.2 (2024): 389.
Chicago
Golijanin, D., Radovanović, Z., Radovanović, D., Đermanović, A., Starčević, S., Đermanović, M."Molecular subtype and risk of local recurrence after nipple‑sparing mastectomy for breast cancer". Oncology Letters 28, no. 2 (2024): 389. https://doi.org/10.3892/ol.2024.14522