Open Access

Gastric granular cell tumor: A case report and literature review

  • Authors:
    • Huixi Li
    • Miao Zhang
    • Youyou Zheng
    • Hong Zhang
  • View Affiliations

  • Published online on: June 27, 2024     https://doi.org/10.3892/ol.2024.14536
  • Article Number: 403
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Granular cell tumors (GCTs) are neoplasms of uncertain histopathological etiology and therefore there are no universally accepted treatment strategies. GCTs are characterized by abundant eosinophilic granules. Since they are predominantly located in the skin and subcutaneous tissues, gastric GCTs are exceedingly rare. The present study documents the case of a 52‑year‑old man who visited the Gastroenterology Clinic of the People's Hospital of Putuo District (Zhoushan, China) due to upper abdominal fullness. Endoscopic ultrasonography revealed a well‑defined hypoechoic nodule in the submucosal layer of the stomach body. The lesion was completely excised using endoscopic submucosal dissection and the patient made a full postoperative recovery. Immunohistochemistry showed positivity for S100 and CD68, with CD34 expression surrounding the tumor cells. At telephone follow‑up until May 2024, the patient's fullness and discomfort were noted to be relieved. The characteristics of the CD34 expression pattern may serve as a novel basis for the pathological diagnosis of gastric GCTs. Endoscopic resection is a feasible option for gastric GCTs smaller than 2 cm.
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September-2024
Volume 28 Issue 3

Print ISSN: 1792-1074
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Spandidos Publications style
Li H, Zhang M, Zheng Y and Zhang H: Gastric granular cell tumor: A case report and literature review. Oncol Lett 28: 403, 2024.
APA
Li, H., Zhang, M., Zheng, Y., & Zhang, H. (2024). Gastric granular cell tumor: A case report and literature review. Oncology Letters, 28, 403. https://doi.org/10.3892/ol.2024.14536
MLA
Li, H., Zhang, M., Zheng, Y., Zhang, H."Gastric granular cell tumor: A case report and literature review". Oncology Letters 28.3 (2024): 403.
Chicago
Li, H., Zhang, M., Zheng, Y., Zhang, H."Gastric granular cell tumor: A case report and literature review". Oncology Letters 28, no. 3 (2024): 403. https://doi.org/10.3892/ol.2024.14536