Open Access

Role of microRNAs in triple‑negative breast cancer and new therapeutic concepts (Review)

  • Authors:
    • Shaofeng Yang
    • Donghai Li
  • View Affiliations

  • Published online on: July 11, 2024     https://doi.org/10.3892/ol.2024.14565
  • Article Number: 431
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer has surpassed lung cancer as the most prevalent malignancy affecting women worldwide. Triple‑negative breast cancer (TNBC) is the type of breast cancer with the worst prognosis. As a heterogeneous disease, TNBC has a pathogenesis that involves multiple oncogenic pathways, including involvement of gene mutations and alterations in signaling pathways. MicroRNAs (miRNAs) are small endogenous, single‑stranded non‑coding RNAs that bind to the 3' untranslated region of target cell mRNAs to negatively regulate the gene expression of these specific mRNAs. Therefore, miRNAs are involved in cell growth, development, division and differentiation stages. miRNAs are also involved in gene targeting in tumorigenesis, tumor growth and the regulation of metastasis, including in breast cancer. Meanwhile, miRNAs also regulate components of signaling pathways. In this review, the role of miRNAs in the TNBC signaling pathway discovered in recent years is described in detail. The new concept of bi‑targeted therapy for breast cancer using miRNA and artificial intelligence is also discussed.
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September-2024
Volume 28 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yang S and Li D: Role of microRNAs in triple‑negative breast cancer and new therapeutic concepts (Review). Oncol Lett 28: 431, 2024.
APA
Yang, S., & Li, D. (2024). Role of microRNAs in triple‑negative breast cancer and new therapeutic concepts (Review). Oncology Letters, 28, 431. https://doi.org/10.3892/ol.2024.14565
MLA
Yang, S., Li, D."Role of microRNAs in triple‑negative breast cancer and new therapeutic concepts (Review)". Oncology Letters 28.3 (2024): 431.
Chicago
Yang, S., Li, D."Role of microRNAs in triple‑negative breast cancer and new therapeutic concepts (Review)". Oncology Letters 28, no. 3 (2024): 431. https://doi.org/10.3892/ol.2024.14565