Open Access

Long non‑coding RNAs as diagnostic and prognostic biomarkers for colorectal cancer (Review)

  • Authors:
    • Yuning Lin
    • Wenzhen Zhao
    • Ruonan Pu
    • Zhenyi Lv
    • Hongyan Xie
    • Ying Li
    • Zhongying Zhang
  • View Affiliations

  • Published online on: August 8, 2024     https://doi.org/10.3892/ol.2024.14619
  • Article Number: 486
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) ranks as the 3rd most common cancer globally and is the 2nd leading cause of cancer‑related death. Owing to the lack of specific early symptoms and the limitations of existing early diagnostic methods, most patients with CRC are diagnosed at advanced stages. To overcome these challenges, researchers have increasingly focused on molecular biomarkers, with particular interest in long non‑coding RNAs (lncRNAs). These non‑protein‑coding RNAs, which exceed 200 nucleotides in length, play critical roles in the development and progression of CRC. The stability and detectability of lncRNAs in the circulatory system make them promising candidate biomarkers. The analysis of circulating lncRNAs in peripheral blood represents a potential option for minimally invasive diagnostic tests based on liquid biopsy samples. The present review aimed to evaluate the efficacy of lncRNAs with altered expression levels in peripheral blood as diagnostic markers for CRC. Additionally, the clinical significance of lncRNAs as prognostic markers for this disease were summarized.
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October-2024
Volume 28 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Lin Y, Zhao W, Pu R, Lv Z, Xie H, Li Y and Zhang Z: Long non‑coding RNAs as diagnostic and prognostic biomarkers for colorectal cancer (Review). Oncol Lett 28: 486, 2024.
APA
Lin, Y., Zhao, W., Pu, R., Lv, Z., Xie, H., Li, Y., & Zhang, Z. (2024). Long non‑coding RNAs as diagnostic and prognostic biomarkers for colorectal cancer (Review). Oncology Letters, 28, 486. https://doi.org/10.3892/ol.2024.14619
MLA
Lin, Y., Zhao, W., Pu, R., Lv, Z., Xie, H., Li, Y., Zhang, Z."Long non‑coding RNAs as diagnostic and prognostic biomarkers for colorectal cancer (Review)". Oncology Letters 28.4 (2024): 486.
Chicago
Lin, Y., Zhao, W., Pu, R., Lv, Z., Xie, H., Li, Y., Zhang, Z."Long non‑coding RNAs as diagnostic and prognostic biomarkers for colorectal cancer (Review)". Oncology Letters 28, no. 4 (2024): 486. https://doi.org/10.3892/ol.2024.14619