Open Access

Liquid biopsy: Comprehensive overview of circulating tumor DNA (Review)

  • Authors:
    • Qian Ge
    • Zhi-Yun Zhang
    • Suo-Ni Li
    • Jie-Qun Ma
    • Zheng Zhao
  • View Affiliations

  • Published online on: September 13, 2024     https://doi.org/10.3892/ol.2024.14681
  • Article Number: 548
  • Copyright: © Ge et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Traditional tumor diagnosis methods rely on tissue biopsy, which can be invasive and unsuitable for long‑term monitoring of tumor dynamics. The advent of liquid biopsy has notably improved the overall management of patients with cancer. Liquid biopsy techniques primarily involve detection of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). The present review focuses on ctDNA because of its significance in tumor diagnosis, monitoring and treatment. The use of ctDNA‑based liquid biopsy offers several advantages, including non‑invasive or minimally invasive collection methods, the ability to conduct repeated assessment and comprehensive insights into tumor biology. It serves crucial roles in disease management by facilitating screening of high‑risk patients, dynamically monitoring therapeutic responses and diagnosis. Furthermore, ctDNA can be used to demonstrate pseudo‑progression, monitor postoperative tumor status and guide adaptive treatment plans. The present study provides a comprehensive review of ctDNA, exploring its origins, metabolism, detection methods, clinical role and the current challenges associated with its application.
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November-2024
Volume 28 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Ge Q, Zhang Z, Li S, Ma J and Zhao Z: Liquid biopsy: Comprehensive overview of circulating tumor DNA (Review). Oncol Lett 28: 548, 2024.
APA
Ge, Q., Zhang, Z., Li, S., Ma, J., & Zhao, Z. (2024). Liquid biopsy: Comprehensive overview of circulating tumor DNA (Review). Oncology Letters, 28, 548. https://doi.org/10.3892/ol.2024.14681
MLA
Ge, Q., Zhang, Z., Li, S., Ma, J., Zhao, Z."Liquid biopsy: Comprehensive overview of circulating tumor DNA (Review)". Oncology Letters 28.5 (2024): 548.
Chicago
Ge, Q., Zhang, Z., Li, S., Ma, J., Zhao, Z."Liquid biopsy: Comprehensive overview of circulating tumor DNA (Review)". Oncology Letters 28, no. 5 (2024): 548. https://doi.org/10.3892/ol.2024.14681